Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5243083 | 0.86 | KMT2A (0.49) | SMN1; SMN2KMT2ANPC1POLBHCRTR1 | |
| SCHEMBL5243022 | 0.84 | ALDH1A1 (0.42) | KMT2AALDH1A1HTTTSHRLMNA | |
| SCHEMBL5280780 | 0.80 | BCHE (0.52) | KMT2AALDH1A1TSHRLMNAMAPT | |
| SCHEMBL5276265 | 0.80 | MCL1 (0.42) | SMN1; SMN2ALDH1A1HTTTSHRLMNA | |
| SCHEMBL5241937 | 0.79 | BCHE (0.44) | SMN1; SMN2KMT2ANPC1POLBHCRTR1 | |
| SCHEMBL5280235 | 0.79 | SMN1; SMN2 (0.51) | SMN1; SMN2KMT2ANPC1POLBHCRTR1 | |
| SCHEMBL5350976 | 0.78 | KMT2A (0.55) | KMT2AALDH1A1HTTGAANPSR1 | |
| SCHEMBL5289084 | 0.77 | SMN1; SMN2 (0.61) | SMN1; SMN2KMT2ANPC1POLBHCRTR1 | |
| SCHEMBL5240550 | 0.76 | ALDH1A1 (0.59) | SMN1; SMN2KMT2ANPC1POLBALDH1A1 | |
| SCHEMBL5239213 | 0.75 | P2RX4 (0.44) | KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833797-A1 | AZACYCLIC COMPOUNDS AS INHBITORS OF SENSORY NEURONE SPECIFIC CHANNELS (SNS) | VERNALIS (R&D) LTD (GB) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006082354-A1 | AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC CHANNELS ( SNS ) | VERNALIS (R & D) LIMITED (GB) | 2006-08-10 | — | — | WO | disclosed |