Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HTR1A | P08908 | 5/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5241842 | 0.90 | LMNA (0.43) | LMNAMAPTDRD2HTR2AMEN1 | |
| SCHEMBL5244012 | 0.87 | LMNA (0.41) | LMNAMAPTHTR1ADRD2HTR2A | |
| SCHEMBL5242687 | 0.85 | LMNA (0.43) | LMNAMAPTHTR1AMEN1KMT2A | |
| SCHEMBL6628361 | 0.83 | LMNA (0.56) | LMNAMAPTHTR1ADRD2HTR2A | |
| SCHEMBL6625036 | 0.82 | LMNA (0.55) | LMNAMAPTHTR1ADRD2HTR2A | |
| SCHEMBL5242970 | 0.81 | LMNA (0.43) | LMNAMAPTHTR1ADRD2HTR2A | |
| SCHEMBL5242930 | 0.81 | HTR1A (0.43) | HTR1ADRD2 | |
| SCHEMBL5183561 | 0.79 | LMNA (0.52) | LMNAMAPTHTR7MEN1KMT2A | |
| SCHEMBL5244935 | 0.79 | LMNA (0.41) | LMNAMAPTHTR1ADRD2HTR2A | |
| SCHEMBL5245094 | 0.79 | SUV39H2 (0.44) | LMNAMAPTHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756107-A2 | ARYL-SUBSTITUTED PIPERAZINE DERIVATIVES | NEUROGEN CORPORATION (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2006009789-A2 | ARYL-SUBSTITUTED PIPERAZINE DERIVATIVES | NEUROGEN CORPORATION (US) | 2006-01-26 | — | — | WO | claimed |