Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 12/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5243868 | 0.81 | LMNA (0.45) | HTR1ADRD2 | |
| SCHEMBL5905159 | 0.80 | OGA (0.39) | HTR1ASLC6A4P2RY12 | |
| SCHEMBL5241842 | 0.79 | LMNA (0.43) | DRD2 | |
| SCHEMBL5244012 | 0.77 | LMNA (0.41) | HTR1ADRD2 | |
| SCHEMBL5242687 | 0.74 | LMNA (0.43) | HTR1A | |
| SCHEMBL6628361 | 0.74 | LMNA (0.56) | HTR1ADRD2 | |
| SCHEMBL6625036 | 0.71 | LMNA (0.55) | HTR1ADRD2 | |
| SCHEMBL5242970 | 0.70 | LMNA (0.43) | HTR1ADRD2 | |
| SCHEMBL4780781 | 0.70 | HTR2A (0.40) | HTR1ASLC6A4P2RY12 | |
| SCHEMBL27357405 | 0.69 | HTR1A (0.59) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756107-A2 | ARYL-SUBSTITUTED PIPERAZINE DERIVATIVES | NEUROGEN CORPORATION (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2006009789-A2 | ARYL-SUBSTITUTED PIPERAZINE DERIVATIVES | NEUROGEN CORPORATION (US) | 2006-01-26 | — | — | WO | claimed |