Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5243868 | 0.85 | LMNA (0.45) | LMNAMAPTMEN1KMT2AHTR1A | |
| SCHEMBL5241842 | 0.83 | LMNA (0.43) | LMNAMAPTMEN1KMT2AABCB1 | |
| SCHEMBL5244012 | 0.81 | LMNA (0.41) | LMNAMAPTMEN1KMT2AHTR1A | |
| SCHEMBL5242682 | 0.78 | ADAMTS5 (0.39) | MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL5183035 | 0.76 | LMNA (0.49) | LMNAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6628361 | 0.76 | LMNA (0.56) | LMNAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL5242970 | 0.74 | LMNA (0.43) | LMNAMAPTABCB1HTR1A | |
| SCHEMBL5242930 | 0.74 | HTR1A (0.43) | HTR1A | |
| SCHEMBL6625036 | 0.73 | LMNA (0.55) | LMNAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL5183561 | 0.73 | LMNA (0.52) | LMNAMAPTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756107-A2 | ARYL-SUBSTITUTED PIPERAZINE DERIVATIVES | NEUROGEN CORPORATION (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2006009789-A2 | ARYL-SUBSTITUTED PIPERAZINE DERIVATIVES | NEUROGEN CORPORATION (US) | 2006-01-26 | — | — | WO | claimed |