Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARNT | P27540 | 2/20 | 0.50 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.50 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 8/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5243660 | 0.82 | ABCC8 (0.46) | ARNTEPAS1MEN1KMT2AKIF11 | |
| SCHEMBL5244253 | 0.81 | MAPT (0.50) | ARNTEPAS1MEN1KMT2AKEAP1 | |
| SCHEMBL5245799 | 0.81 | KDM4E (0.41) | ARNTEPAS1SCN2AALOX15ALOX12 | |
| SCHEMBL4787990 | 0.81 | ARNT (0.47) | ARNTEPAS1SCN2AMEN1KMT2A | |
| SCHEMBL8153946 | 0.79 | BRD4 (0.45) | ARNTEPAS1ABCG2MEN1KMT2A | |
| SCHEMBL4788108 | 0.78 | KDM4E (0.46) | ARNTEPAS1SCN2AMAPT | |
| SCHEMBL5245136 | 0.77 | NPBWR1 (0.44) | ARNTEPAS1MEN1KMT2AKEAP1 | |
| SCHEMBL5243653 | 0.76 | ARNT (0.45) | ARNTEPAS1MEN1KMT2AKEAP1 | |
| SCHEMBL5244995 | 0.75 | MAPT (0.45) | MEN1KMT2AKEAP1NFE2L2MAPT | |
| SCHEMBL5301588 | 0.74 | MEN1 (0.50) | ARNTEPAS1MEN1KMT2AMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758873-A1 | UBIQUITIN LIGASE INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2006002284-A1 | UBIQUITIN LIGASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2006-01-05 | — | — | WO | claimed |
| US-20050282818-A1 | Ubiquitin ligase inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2005-12-22 | — | — | US | claimed |
| US-20050282818-A1 | Ubiquitin ligase inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2005-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282818-A1 | Ubiquitin ligase inhibitors | NEDD4, TRAF6, XIAP | ARNT 1732/4885EPAS1 1966/4885SCN2A 4683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.