Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PREP | P48147 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10782598 | 1.00 | HSD17B10 (0.47) | HSD17B10HPGDEPHX1SMN1; SMN2PREP | |
| SCHEMBL7355124 | 0.89 | HSD17B10 (0.43) | HSD17B10HPGDEPHX1SMN1; SMN2USP2 | |
| SCHEMBL27720507 | 0.88 | HPGD (0.47) | HSD17B10HPGDEPHX1SMN1; SMN2PREP | |
| SCHEMBL26603927 | 0.88 | HPGD (0.47) | HSD17B10HPGDEPHX1SMN1; SMN2PREP | |
| SCHEMBL28516773 | 0.84 | HPGD (0.49) | HSD17B10HPGDEPHX1SMN1; SMN2PREP | |
| SCHEMBL28100905 | 0.84 | HPGD (0.49) | HSD17B10HPGDEPHX1SMN1; SMN2PREP | |
| SCHEMBL27999183 | 0.83 | HSD17B10 (0.48) | HSD17B10HPGDEPHX1SMN1; SMN2USP2 | |
| SCHEMBL28104634 | 0.81 | KDM4E (0.47) | NPC1GPR119 | |
| SCHEMBL15221624 | 0.80 | HPGD (0.46) | HSD17B10HPGDEPHX1SMN1; SMN2PREP | |
| SCHEMBL31197652 | 0.80 | HPGD (0.46) | HSD17B10HPGDEPHX1SMN1; SMN2PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831197-A2 | SUBSTITUTED OXINDOLE DERIVATIVES, MEDICAMENTS CONTAINING SAID DERIVATIVES AND USE THEREOF | Abbott GmbH & Co. KG (DE) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006072458-A2 | SUBSTITUTED OXINDOLE DERIVATIVES, MEDICAMENTS CONTAINING SAID DERIVATIVES AND USE THEREOF | ABBOTT GMBH & CO. KG (DE) | 2006-07-13 | — | — | WO | disclosed |
| EP-0310918-A2 | Peptide-like amino-acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1989-04-12 | — | — | EP | disclosed |