Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.43 |
| ▸ | KIF11 | P52732 | 3/20 | 0.41 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.41 |
| ▸ | GNRHR | P30968 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5742421 | 0.90 | KIF11 (0.40) | TLR7KIF11KIF23GNRHRBRD4 | |
| SCHEMBL5248653 | 0.88 | KIF11 (0.42) | TLR7KIF11KIF23GNRHRSIGMAR1 | |
| SCHEMBL5246236 | 0.85 | KIF11 (0.52) | TLR7KIF11KIF23GNRHRSIGMAR1 | |
| SCHEMBL5740939 | 0.84 | KIF11 (0.47) | TLR7KIF11KIF23GNRHRSIGMAR1 | |
| SCHEMBL5246052 | 0.83 | TLR7 (0.43) | TLR7KIF11GNRHRSIGMAR1NPSR1 | |
| SCHEMBL3871323 | 0.82 | KIF11 (0.49) | TLR7KIF11KIF23SIGMAR1NPSR1 | |
| SCHEMBL3863849 | 0.82 | KIF11 (0.49) | TLR7KIF11KIF23GNRHRSIGMAR1 | |
| SCHEMBL6207102 | 0.82 | KIF11 (0.45) | KIF11KIF23NPSR1PDE4APDE4B | |
| SCHEMBL5740657 | 0.81 | KIF11 (0.46) | TLR7KIF11KIF23SIGMAR1BRD4 | |
| SCHEMBL5248649 | 0.80 | KIF11 (0.45) | TLR7KIF11KIF23GNRHRSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628981-A2 | BICYCLICPYRIMIDONES AND THEIR USE TO TREAT DISEASES | Bristol-Myers Squibb Company (US) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004106492-A2 | BICYCLICPYRIMIDONES AND THEIR USE TO TREAT DISEASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-12-09 | — | — | WO | disclosed |