Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 6/20 | 0.47 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.38 |
| ▸ | GNRHR | P30968 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5246236 | 0.95 | KIF11 (0.52) | KIF11KIF23TLR7GNRHRMC4R | |
| SCHEMBL4066353 | 0.87 | KIF11 (0.45) | KIF11KIF23GNRHRMC4RSMN1; SMN2 | |
| SCHEMBL5739482 | 0.87 | KIF11 (0.51) | KIF11KIF23MAPT | |
| SCHEMBL3959159 | 0.86 | KIF11 (0.60) | KIF11KIF23 | |
| SCHEMBL5247152 | 0.85 | KIF11 (0.52) | KIF11KIF23MC4R | |
| SCHEMBL5740661 | 0.84 | TLR7 (0.43) | KIF11KIF23TLR7GNRHRSIGMAR1 | |
| SCHEMBL4044239 | 0.84 | KIF11 (0.68) | KIF11KIF23 | |
| SCHEMBL3961576 | 0.82 | KIF11 (0.57) | KIF11KIF23 | |
| SCHEMBL3905973 | 0.81 | KIF11 (0.51) | KIF11KIF23TLR7GNRHRMC4R | |
| SCHEMBL3957584 | 0.81 | KIF11 (0.57) | KIF11KIF23 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628981-A2 | BICYCLICPYRIMIDONES AND THEIR USE TO TREAT DISEASES | Bristol-Myers Squibb Company (US) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004106492-A2 | BICYCLICPYRIMIDONES AND THEIR USE TO TREAT DISEASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-12-09 | — | — | WO | disclosed |