Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.51 |
| ▸ | DRD3 | P35462 | 6/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.43 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 4/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | C1S | P09871 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MLYCD | O95822 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5243882 | 0.85 | POLB (0.48) | DRD2DRD3DRD4HTR1APOLB | |
| SCHEMBL18581653 | 0.83 | DRD2 (0.41) | DRD2DRD3NOTUM | |
| SCHEMBL20195330 | 0.83 | DRD2 (0.41) | DRD2DRD3NOTUM | |
| SCHEMBL5244482 | 0.81 | ALDH1A1 (0.44) | DRD2DRD4HTR1APOLB | |
| SCHEMBL15800697 | 0.77 | DRD2 (0.79) | DRD2DRD3NOTUMSLC2A1SLC2A2 | |
| SCHEMBL5247322 | 0.73 | DRD2 (0.42) | DRD2DRD3DRD4HTR1APOLB | |
| SCHEMBL3537217 | 0.71 | DRD2 (0.74) | DRD2DRD3NOTUMSLC2A1SLC2A2 | |
| SCHEMBL29809089 | 0.71 | DRD2 (0.74) | DRD2DRD3NOTUMSLC2A1SLC2A2 | |
| SCHEMBL22495307 | 0.71 | DRD2 (0.64) | DRD2DRD3NOTUMSLC2A1SLC2A2 | |
| SCHEMBL5245726 | 0.70 | LMNA (0.54) | DRD2DRD3DRD4HTR1APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1866298-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2007-12-19 | — | — | EP | claimed |
| WO-2006105127-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-10-05 | — | — | WO | claimed |