Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8264443 | 0.79 | KMT2A (0.48) | SMN1; SMN2KMT2ALMNARAB9AALDH1A1 | |
| SCHEMBL20869137 | 0.72 | CCR5 (0.58) | SMN1; SMN2KMT2ALMNARAB9ANPC1 | |
| SCHEMBL3988013 | 0.71 | LMNA (0.56) | SMN1; SMN2KMT2ALMNARAB9ANPC1 | |
| SCHEMBL15270920 | 0.70 | KMT2A (0.55) | SMN1; SMN2KMT2ALMNARAB9ANPC1 | |
| SCHEMBL15452368 | 0.70 | LTA4H (0.53) | SMN1; SMN2KMT2ALMNARAB9ANPC1 | |
| SCHEMBL29442826 | 0.70 | BACE1 (0.50) | SMN1; SMN2KMT2ARAB9ANPC1HTT | |
| SCHEMBL18210531 | 0.70 | LMNA (0.45) | SMN1; SMN2KMT2ALMNARAB9AHTT | |
| SCHEMBL1002382 | 0.69 | LTA4H (0.59) | SMN1; SMN2KMT2ARAB9ANPC1HTT | |
| SCHEMBL6964474 | 0.69 | SMN1; SMN2 (0.58) | SMN1; SMN2KMT2ALMNARAB9ANPC1 | |
| SCHEMBL20270067 | 0.69 | ALDH1A1 (0.59) | SMN1; SMN2KMT2ALMNARAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831170-A1 | SUBSTITUTED AMINOPYRIDINES AND USES THEREOF | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006065204-A1 | SUBSTITUTED AMINOPYRIDINES AND USES THEREOF | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | disclosed |