Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.78 |
| ▸ | MEN1 | O00255 | 4/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | TDO2 | P48775 | 2/20 | 0.54 |
| ▸ | IDO2 | Q6ZQW0 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5251485 | 0.88 | KMT2A (0.72) | KMT2AMEN1ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL5254527 | 0.86 | ALDH1A1 (0.66) | KMT2AMEN1ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL5248590 | 0.84 | ALDH1A1 (0.63) | KMT2AMEN1ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL5253405 | 0.83 | KMT2A (0.65) | KMT2AMEN1ALDH1A1RAB9ATDO2 | |
| SCHEMBL4061235 | 0.83 | MEN1 (0.56) | KMT2AMEN1ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL7770196 | 0.79 | ALDH1A1 (0.86) | KMT2AMEN1ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL14571461 | 0.79 | KMT2A (0.60) | KMT2AMEN1ALDH1A1RAB9ATDO2 | |
| SCHEMBL2631381 | 0.79 | MAPK1 (0.74) | ALDH1A1SMN1; SMN2NPSR1RAB9ALMNA | |
| SCHEMBL5248270 | 0.78 | KDM4E (0.65) | KMT2AMEN1ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL22736778 | 0.77 | ALDH1A1 (0.60) | KMT2AMEN1ALDH1A1SMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696927-A4 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2007-10-31 | — | — | EP | claimed |
| US-20070060601-A1 | Mitotic kinesin inhibitors | MERCK SHARP & DOHME CORP. | 2007-03-15 | — | — | US | claimed |
| EP-1696927-A2 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2006-09-06 | — | — | EP | claimed |
| WO-2005065183-A2 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2005-07-21 | — | — | WO | claimed |
| EP-1696927-A4 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2007-10-31 | — | — | EP | disclosed |
| US-20070060601-A1 | Mitotic kinesin inhibitors | MERCK SHARP & DOHME CORP. | 2007-03-15 | — | — | US | disclosed |
| US-20070060601-A1 | Mitotic kinesin inhibitors | MERCK SHARP & DOHME CORP. | 2007-03-15 | — | — | US | disclosed |
| US-20070060601-A1 | Mitotic kinesin inhibitors | MERCK SHARP & DOHME CORP. | 2007-03-15 | — | — | US | disclosed |
| EP-1696927-A2 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005065183-A2 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2005-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060601-A1 | Mitotic kinesin inhibitors | KIF5B, KIF2C, KIF18B | KMT2A 390/4885MEN1 2229/4885ALDH1A1 2586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.