Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 13/20 | 0.54 |
| ▸ | CA12 | O43570 | 12/20 | 0.49 |
| ▸ | CA1 | P00915 | 12/20 | 0.49 |
| ▸ | CA6 | P23280 | 12/20 | 0.49 |
| ▸ | CA5A | P35218 | 12/20 | 0.49 |
| ▸ | CA7 | P43166 | 12/20 | 0.49 |
| ▸ | CA13 | Q8N1Q1 | 12/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 12/20 | 0.49 |
| ▸ | CA9 | Q16790 | 11/20 | 0.49 |
| ▸ | CA5B | Q9Y2D0 | 11/20 | 0.49 |
| ▸ | CA3 | P07451 | 10/20 | 0.49 |
| ▸ | CA4 | P22748 | 9/20 | 0.49 |
| ▸ | NAAA | Q02083 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5245397 | 0.78 | CA2 (0.53) | CA2CA1ALDH1A1KMT2A | |
| SCHEMBL20434471 | 0.75 | NAAA (0.54) | NAAAALDH1A1CYP1A2GAACYP2C9 | |
| SCHEMBL2012299 | 0.75 | NAAA (0.54) | NAAAALDH1A1CYP1A2GAACYP2C9 | |
| SCHEMBL20434453 | 0.75 | NAAA (0.54) | NAAAALDH1A1CYP1A2GAACYP2C9 | |
| SCHEMBL7629408 | 0.74 | ALDH1A1 (0.43) | CA2CA1ALDH1A1KDM4EKMT2A | |
| SCHEMBL6586902 | 0.74 | KMT2A (0.62) | CA2CA12CA1CA6CA5A | |
| SCHEMBL20436876 | 0.72 | NAAA (0.54) | NAAAALDH1A1CYP1A2GAACYP2C9 | |
| SCHEMBL6157351 | 0.72 | CA2 (0.47) | CA2CA12CA1CA6CA5A | |
| SCHEMBL13858907 | 0.71 | HPGD (0.55) | NAAAALDH1A1CYP1A2GAACYP2C9 | |
| SCHEMBL7810359 | 0.71 | ALOX15 (0.55) | CA2NAAAALDH1A1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1533311-B1 | Sulfonamides and derivatives thereof that modulate the activity of endothelin | ENCYSIVE PHARMACEUTICALS INC (US) | 2007-04-25 | — | — | EP | disclosed |
| EP-1533311-A1 | Sulfonamides and derivatives thereof that modulate the activity of endothelin | ENCYSIVE PHARMACEUTICALS INC. (US) | 2005-05-25 | — | — | EP | disclosed |
| EP-1244657-B1 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | ENCYSIVE PHARMACEUTICALS INC (US) | 2004-12-29 | — | — | EP | disclosed |
| EP-0946552-B1 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | ENCYSIVE PHARMACEUTICALS INC (US) | 2004-07-07 | — | — | EP | disclosed |
| US-6686382-B2 | N-(ISOXAZOLYL)THIENYLSULFONAMIDES, N-(ISOXAZOLYL)FURYLSULFONAMIDES, N-(ISOXAZOLYL)PYRROLYLSULFONAMIDES AND N-(ISOXAZOLYL)PHENYLSULFONAMIDES; INHIBIT ENDOTHELIN | ENCYSIVE PHARMACEUTICALS INC. | 2004-02-03 | — | — | US | disclosed |
| US-20030208084-A1 | Sulfonamides and derivatives thereof that modulate the activity of endothelin | ENCYSIVE PHARMACEUTICALS INC. | 2003-11-06 | — | — | US | disclosed |
| US-6632829-B2 | Thienyl, furyl and pyrrolyl-sulfonamides, useful for treating hypertension, cardiovascular disease, asthma, pulmonary hypertension, inflammatory diseases, vision defects, menstrual disorders, renal failure and other diseases | TEXAS BIOTECHNOLOGY CORP. | 2003-10-14 | — | — | US | disclosed |
| EP-1342721-A1 | Sulfonamides and derivatives thereof that modulate the activity of endothelin | ENCYSIVE PHARMACEUTICALS INC. (US) | 2003-09-10 | — | — | EP | disclosed |
| EP-1244657-A2 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2002-10-02 | — | — | EP | disclosed |
| US-20020091272-A1 | Sulfonamides and derivatives thereof that modulate the activity of endothelin | ENCYSIVE PHARMACEUTICALS INC. | 2002-07-11 | — | — | US | disclosed |
| US-20010056183-A1 | Sulfonamides and derivatives thereof that modulate the activity of endothelin | TEXAS BIOTECHNOLOGY CORPORATION | 2001-12-27 | — | — | US | disclosed |
| WO-2001049685-A2 | SULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030208084-A1 | Sulfonamides and derivatives thereof that modulate the activity of endothelin | EDNRA, EDNRB, ECE1 | CA2 922/4885CA12 2690/4885CA1 2564/4885 |
| US-20010056183-A1 | Sulfonamides and derivatives thereof that modulate the activity of endothelin | EDNRA, EDNRB, ECE1 | CA2 1646/4885CA12 3904/4885CA1 3910/4885 |
| US-20020091272-A1 | Sulfonamides and derivatives thereof that modulate the activity of endothelin | EDNRA, EDNRB, ECE1 | CA2 922/4885CA12 2690/4885CA1 2564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.