Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14081574 | 0.77 | GRM5 (0.53) | GRM5ALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL5905121 | 0.76 | DRD2 (0.52) | — | |
| SCHEMBL5194325 | 0.75 | DRD2 (0.48) | ALDH1A1 | |
| SCHEMBL5193723 | 0.74 | DRD2 (0.48) | — | |
| SCHEMBL5798011 | 0.74 | DRD2 (0.43) | — | |
| SCHEMBL5195811 | 0.73 | DRD2 (0.40) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL5798010 | 0.72 | OPRM1 (0.43) | — | |
| SCHEMBL5196784 | 0.72 | HTR4 (0.36) | BRAFSMN1; SMN2MAPTMAPK1 | |
| SCHEMBL5194165 | 0.71 | DRD2 (0.40) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL5905435 | 0.70 | DRD2 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809626-A2 | ARYL SUBSTITUTED 8-AZABICYCLO[3.2.1]OCTANE COMPOUNDS AS LIGANDS OF THE MELANIN CONCENTRATING HORMONE RECEPTOR | Neurogen Corporation (US) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006044174-A9 | ARYL SUBSTITUTED 8-AZABICYCLO[3.2.1]OCTANE COMPOUNDS AS LIGANDS OF THE MELANIN CONCENTRATING HORMONE RECEPTOR | NEUROGEN CORP (US) | 2006-07-20 | — | — | WO | disclosed |
| WO-2006044174-A2 | ARYL SUBSTITUTED 8-AZABICYCLO[3.2.1]OCTANE COMPOUNDS AS LIGANDS OF THE MELANIN CONCENTRATING HORMONE RECEPTOR | NEUROGEN CORPORATION (US) | 2006-04-27 | — | — | WO | disclosed |