Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.42 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 5/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.36 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740661 | 0.88 | TLR7 (0.43) | KIF11KIF23BRD4TLR7GNRHR | |
| SCHEMBL5250052 | 0.85 | KIF11 (0.40) | KIF11BRD4TLR7GNRHRSIGMAR1 | |
| SCHEMBL5247152 | 0.83 | KIF11 (0.52) | KIF11KIF23CYP3A4 | |
| SCHEMBL3863849 | 0.82 | KIF11 (0.49) | KIF11KIF23BRD4TLR7GNRHR | |
| SCHEMBL3871323 | 0.81 | KIF11 (0.49) | KIF11KIF23BRD4TLR7SIGMAR1 | |
| SCHEMBL4753082 | 0.80 | TLR7 (0.41) | KIF11BRD4TLR7GNRHRCYP3A4 | |
| SCHEMBL4753094 | 0.80 | GNRHR (0.41) | KIF11BRD4TLR7GNRHRCYP3A4 | |
| SCHEMBL4883072 | 0.80 | KIF11 (0.41) | KIF11KIF23 | |
| SCHEMBL5248649 | 0.79 | KIF11 (0.45) | KIF11KIF23BRD4TLR7GNRHR | |
| SCHEMBL5742421 | 0.79 | KIF11 (0.40) | KIF11KIF23BRD4TLR7GNRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781674-A1 | ENANTIOMERS OF SELECTED FUSED PYRIMIDONES AND USES IN THE TREATMENT AND PREVENTION OF CANCER | AstraZeneca AB (SE) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006018628-A1 | ENANTIOMERS OF SELECTED FUSED PYRIMIDONES AND USES IN THE TREATMENT AND PREVENTI ON OF CANCER | ASTRAZENECA AB (SE) | 2006-02-23 | — | — | WO | disclosed |
| EP-1601673-A1 | NOVEL FUSED HETEROCYCLES AND USES THEREOF | AstraZeneca AB (SE) | 2005-12-07 | — | — | EP | disclosed |
| WO-2004078758-A1 | NOVEL FUSED HETEROCYCLES AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-16 | — | — | WO | disclosed |