Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | RARA | P10276 | 3/20 | 0.34 |
| ▸ | RARB | P10826 | 3/20 | 0.34 |
| ▸ | RARG | P13631 | 3/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | STAT1 | P42224 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5252128 | 0.83 | RARA (0.41) | SIRT2SIRT1RARARARBRARG | |
| SCHEMBL382430 | 0.78 | RARG (0.48) | SIRT2SIRT1RARARARBRARG | |
| SCHEMBL382163 | 0.72 | HRH3 (0.43) | SIRT2SIRT1NPC1MAPTRAB9A | |
| SCHEMBL382484 | 0.68 | RARG (0.63) | SIRT2SIRT1RARARARBRARG | |
| SCHEMBL15033636 | 0.66 | CHKA (0.44) | NPC1MAPTRAB9AALDH1A1LMNA | |
| SCHEMBL382829 | 0.66 | RARG (0.65) | SIRT2SIRT1RARARARBRARG | |
| SCHEMBL381628 | 0.63 | PDGFRB (0.41) | NPC1MAPTRAB9AALDH1A1HPGD | |
| SCHEMBL17857889 | 0.63 | HTR1A (0.53) | NPC1MAPTRAB9AALDH1A1LMNA | |
| SCHEMBL26139373 | 0.63 | ALDH1A1 (0.48) | NPC1MAPTRAB9AALDH1A1LMNA | |
| SCHEMBL8159908 | 0.63 | MAPT (0.51) | NPC1MAPTRAB9AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831149-A1 | NOVEL LIGANDS THAT MODULATE RAR RECEPTORS AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066978-A1 | NOVEL LIGANDS THAT MODULATE RAR RECEPTORS, AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2006-06-29 | — | — | WO | disclosed |