Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.48 |
| ▸ | HPRT1 | P00492 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | S100A4 | P26447 | 1/20 | 0.44 |
| ▸ | HNF4A | P41235 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL187452 | 0.78 | TSHR (0.65) | TSHRCYP3A4ALDH1A1NCEH1HPRT1 | |
| SCHEMBL3071816 | 0.77 | TSHR (0.62) | TSHRCYP3A4ALDH1A1NCEH1HPRT1 | |
| SCHEMBL1710125 | 0.77 | TSHR (1.00) | TSHRCYP3A4ALDH1A1NCEH1HPRT1 | |
| SCHEMBL2026504 | 0.77 | TSHR (0.62) | TSHRCYP3A4ALDH1A1NCEH1HPRT1 | |
| SCHEMBL15617271 | 0.77 | TSHR (0.62) | TSHRCYP3A4ALDH1A1NCEH1HPRT1 | |
| SCHEMBL3699674 | 0.77 | TSHR (0.62) | TSHRCYP3A4ALDH1A1NCEH1HPRT1 | |
| SCHEMBL10871323 | 0.77 | TSHR (0.62) | TSHRCYP3A4ALDH1A1NCEH1HPRT1 | |
| SCHEMBL767775 | 0.77 | TSHR (0.62) | TSHRCYP3A4ALDH1A1NCEH1HPRT1 | |
| SCHEMBL7936527 | 0.77 | TSHR (0.62) | TSHRCYP3A4ALDH1A1NCEH1HPRT1 | |
| SCHEMBL17987525 | 0.77 | TSHR (0.62) | TSHRCYP3A4ALDH1A1NCEH1HPRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103201270-A | P2x4 receptor antagonist | NIPPON CHEMIPHAR CO | 2013-07-10 | — | — | CN | disclosed |
| CN-101541768-A | P2X4Receptor antagonists | NIPPON CHEMIPHAR CO (JP) | 2009-09-23 | — | — | CN | disclosed |
| EP-1361225-B1 | COMPOUNDS SUBSTITUTED WITH BICYCLIC AMINO GROUPS | SANKYO CO (JP) | 2007-11-07 | — | — | EP | disclosed |
| CN-1294129-C | Heteraryl-substituted porrole derivatives, their prep. and therapeutic use | SANKYO CO (JP) | 2007-01-10 | — | — | CN | disclosed |
| US-7122666-B2 | Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses | SANKYO COMPANY, LIMITED (JP) | 2006-10-17 | — | — | US | disclosed |
| US-7091352-B2 | Compounds substituted with bicyclic amino groups | SANKYO COMPANY, LIMITED (JP) | 2006-08-15 | — | — | US | disclosed |
| US-20060128756-A1 | Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses | SANKYO COMPANY, LIMITED (JP) | 2006-06-15 | — | — | US | disclosed |
| EP-1377577-B1 | PYRROLE DERIVATES FOR TREATING CYTOKINE MEDIATED DISEASES | SANKYO CO (JP) | 2006-06-14 | — | — | EP | disclosed |
| US-20050283006-A1 | Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses | SANKYO COMPANY, LIMITED (JP) | 2005-12-22 | — | — | US | disclosed |
| US-20040147525-A1 | Compounds substituted with bicyclic amino groups | SANKYO COMPANY, LIMITED (JP) | 2004-07-29 | — | — | US | disclosed |
| EP-1070711-A2 | Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |
| US-5792840-A | SUBSTITUTED GLUCOPYRANOSYL PHOSPHATES | SANKYO COMPANY, LIMITED (JP) | 1998-08-11 | — | — | US | disclosed |
| EP-0437016-B1 | Lipid A analogues having immunoactivating and anti-tumour activity | SANKYO CO (JP) | 1996-05-01 | — | — | EP | disclosed |
| EP-0437016-A2 | Lipid A analogues having immunoactivating and anti-tumour activity | Sankyo Company Limited (JP) | 1991-07-17 | — | — | EP | disclosed |
| US-4980096-A | Protective coatings; adhesives | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1990-12-25 | — | — | US | disclosed |
| US-4740600-A | UNBLOCKING WITH ACTINIC RADIATION; PROTECTIVE COATING; THERMOPLASTIC RESIN MIXTURES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1988-04-26 | — | — | US | disclosed |
| US-4599273-A | PROTECTIVE COATINGS, PRESSURE SENSITIVE ADHESIVES | MINNESOTA MINING AND MANUFACTURING CO. (US) | 1986-07-08 | — | — | US | disclosed |
| EP-0046083-B1 | PHOTOLABILE BLOCKED SURFACTANTS AND COMPOSITIONS CONTAINING THE SAME | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1985-10-16 | — | — | EP | disclosed |
| US-4478967-A | Photolabile blocked surfactants and compositions containing the same | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1984-10-23 | — | — | US | disclosed |
| EP-0046083-A2 | Photolabile blocked surfactants and compositions containing the same | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1982-02-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128756-A1 | Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses | IL2, IL1A, IL1B | TSHR 598/4885CYP3A4 2846/4885ALDH1A1 871/4885 |
| US-20050283006-A1 | Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses | IL2, CNKSR1, IL1A | TSHR 378/4885CYP3A4 2260/4885ALDH1A1 928/4885 |
| US-20040147525-A1 | Compounds substituted with bicyclic amino groups | IL2, IL1B, IL4I1 | TSHR 1999/4885CYP3A4 83/4885ALDH1A1 507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.