Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 2/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL927263 | 0.89 | LMNA (0.49) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4031469 | 0.87 | MMP8 (0.50) | ALDH1A1LMNAFKBP1AMMP8MMP3 | |
| SCHEMBL926836 | 0.87 | FKBP1A (0.48) | ALDH1A1LMNASMN1; SMN2FKBP1APKM | |
| SCHEMBL5303965 | 0.84 | MAPT (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5302286 | 0.83 | KDM4E (0.53) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5249603 | 0.83 | MMP8 (0.51) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4844911 | 0.83 | MEN1 (0.46) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4840621 | 0.83 | MMP8 (0.42) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5253603 | 0.83 | MMP8 (0.53) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL926246 | 0.81 | EPHX2 (0.48) | ALDH1A1LMNASMN1; SMN2FKBP1APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758884-A2 | N-CYCLIC SULFONAMIDO INHIBITORS OF GAMMA SECRETASE | Elan Pharmaceuticals, Inc. (US) | 2007-03-07 | — | — | EP | claimed |
| US-20060035884-A1 | N-cyclic sulfonamido inhibitors of gamma secretase | ELAN PHARMACEUTICALS, INC. (US) | 2006-02-16 | — | — | US | claimed |
| WO-2005113542-A2 | N-CYCLIC SULFONAMIDO INHIBITORS OF GAMMA SECRETASE | ELAN PHARMACEUTICALS, INC. (US) | 2005-12-01 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060035884-A1 | N-cyclic sulfonamido inhibitors of gamma secretase | BACE1, BACE2, APH1B | ALDH1A1 2985/4885PSEN1 4/4885PSEN2 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.