Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5521150 | 0.87 | MEN1 (0.51) | CYP11B1CYP11B2MEN1KMT2ANPSR1 | |
| SCHEMBL9537317 | 0.85 | MEN1 (0.44) | MEN1KMT2ANPSR1ALOX12ALOX15 | |
| SCHEMBL8439997 | 0.85 | MEN1 (0.47) | CYP11B1CYP11B2MEN1KMT2ANPSR1 | |
| SCHEMBL7832063 | 0.81 | MEN1 (0.47) | CYP11B1CYP11B2MEN1KMT2ANPSR1 | |
| SCHEMBL14686282 | 0.80 | CA1 (0.47) | CYP11B1CYP11B2MEN1KMT2ANPSR1 | |
| SCHEMBL28750722 | 0.79 | ALOX15 (0.60) | MEN1KMT2ANPSR1ALOX12ALOX15 | |
| SCHEMBL18557563 | 0.77 | MEN1 (0.49) | CYP11B1CYP11B2MEN1KMT2ANPSR1 | |
| SCHEMBL5753110 | 0.77 | ALDH1A1 (0.54) | CYP11B1CYP11B2MEN1KMT2AKDM4E | |
| SCHEMBL5510993 | 0.77 | MEN1 (0.48) | MEN1KMT2ANPSR1ALOX12ALOX15 | |
| SCHEMBL1578362 | 0.76 | MEN1 (0.50) | CYP11B1CYP11B2MEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748980-A1 | PYRROLIDINE DERIVATIVES AS CB1-RECEPTOR ANTAGONISTS | TANABE SEIYAKU CO., LTD. (JP) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005115977-A1 | PYRROLIDINE DERIVATIVES AS CB1-RECEPTOR ANTAGONISTS | TANABE SEIYAKU CO., LTD. (JP) | 2005-12-08 | — | — | WO | disclosed |