Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5256231 | 0.90 | TRPV1 (0.34) | HDAC3HDAC1HDAC6TRPV1ADRB3 | |
| SCHEMBL5259963 | 0.88 | ADRB3 (0.37) | HDAC3HDAC1HDAC6TRPV1ADRB3 | |
| SCHEMBL5257628 | 0.85 | CYP3A4 (0.36) | TRPV1P2RX7 | |
| SCHEMBL5255321 | 0.84 | JAK3 (0.37) | ADRB3NAMPT | |
| SCHEMBL5225642 | 0.82 | ITGB1 (0.36) | HDAC3HDAC1HDAC6TRPV1P2RX3 | |
| SCHEMBL5255283 | 0.79 | CA12 (0.37) | HDAC3HDAC1HDAC6TRPV1P2RX3 | |
| SCHEMBL5258338 | 0.77 | NAMPT (0.37) | TRPV1ADRB3NAMPT | |
| SCHEMBL5256333 | 0.75 | FFAR1 (0.37) | TRPV1P2RX7 | |
| SCHEMBL5228649 | 0.73 | ITGB1 (0.37) | HDAC3HDAC1HDAC6TRPV1P2RX3 | |
| SCHEMBL5264743 | 0.73 | TRPV1 (0.42) | HDAC3HDAC1HDAC6TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622867-B1 | N-(2-PHENYLETHYL)SULFAMIDE DERIVATIVES AS INTEGRIN ALPHA4 ANTAGONISTS | ALMIRALL LAB (ES) | 2007-09-19 | — | — | EP | claimed |
| EP-1622867-B1 | N-(2-PHENYLETHYL)SULFAMIDE DERIVATIVES AS INTEGRIN ALPHA4 ANTAGONISTS | ALMIRALL LAB (ES) | 2007-09-19 | — | — | EP | disclosed |