Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 15/20 | 0.65 |
| ▸ | DRD4 | P21917 | 5/20 | 0.64 |
| ▸ | DRD2 | P14416 | 3/20 | 0.64 |
| ▸ | HTR2A | P28223 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5255698 | 1.00 | CCR2 (0.65) | CCR2DRD4DRD2HTR2A | |
| SCHEMBL5258356 | 0.85 | DRD2 (0.64) | DRD4DRD2HTR2A | |
| SCHEMBL5258352 | 0.85 | DRD2 (0.64) | DRD4DRD2HTR2A | |
| SCHEMBL5258616 | 0.84 | DRD2 (0.64) | DRD4DRD2HTR2A | |
| SCHEMBL5258609 | 0.84 | DRD2 (0.64) | DRD4DRD2HTR2A | |
| SCHEMBL5263211 | 0.82 | L3MBTL1 (0.64) | DRD4DRD2HTR2A | |
| SCHEMBL5263219 | 0.82 | L3MBTL1 (0.64) | DRD4DRD2HTR2A | |
| SCHEMBL5257924 | 0.80 | DRD2 (0.66) | DRD4DRD2HTR2A | |
| SCHEMBL5257928 | 0.80 | DRD2 (0.66) | DRD4DRD2HTR2A | |
| SCHEMBL5310457 | 0.80 | DRD4 (0.78) | CCR2DRD4DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1496896-A4 | INHIBITORS OF AKT ACTIVITY | MERCK & CO INC (US) | 2007-10-31 | — | — | EP | claimed |
| EP-1496896-A1 | INHIBITORS OF AKT ACTIVITY | Merck & Co., Inc. (US) | 2005-01-19 | — | — | EP | claimed |
| WO-2003086394-A1 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | claimed |
| EP-1496896-A4 | INHIBITORS OF AKT ACTIVITY | MERCK & CO INC (US) | 2007-10-31 | — | — | EP | disclosed |
| EP-1496896-A1 | INHIBITORS OF AKT ACTIVITY | Merck & Co., Inc. (US) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003086394-A1 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | disclosed |