Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 13/20 | 0.58 |
| ▸ | DRD4 | P21917 | 13/20 | 0.58 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.52 |
| ▸ | CCR3 | P51677 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5263211 | 1.00 | L3MBTL1 (0.64) | L3MBTL1DRD2DRD4PRKAA2CCR3 | |
| SCHEMBL5258352 | 0.88 | DRD2 (0.64) | DRD2DRD4CCR3HTR2AHDAC3 | |
| SCHEMBL5258356 | 0.88 | DRD2 (0.64) | DRD2DRD4CCR3HTR2AHDAC3 | |
| SCHEMBL5258054 | 0.85 | CCR3 (0.62) | DRD2DRD4PRKAA2CCR3HTR2A | |
| SCHEMBL5258050 | 0.85 | CCR3 (0.62) | DRD2DRD4PRKAA2CCR3HTR2A | |
| SCHEMBL5255698 | 0.82 | CCR2 (0.65) | DRD2DRD4HTR2A | |
| SCHEMBL5255707 | 0.82 | CCR2 (0.65) | DRD2DRD4HTR2A | |
| SCHEMBL5258609 | 0.81 | DRD2 (0.64) | DRD2DRD4HTR2A | |
| SCHEMBL5258616 | 0.81 | DRD2 (0.64) | DRD2DRD4HTR2A | |
| SCHEMBL5311843 | 0.81 | DRD2 (0.55) | DRD2DRD4PRKAA2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1496896-A4 | INHIBITORS OF AKT ACTIVITY | MERCK & CO INC (US) | 2007-10-31 | — | — | EP | claimed |
| EP-1496896-A1 | INHIBITORS OF AKT ACTIVITY | Merck & Co., Inc. (US) | 2005-01-19 | — | — | EP | claimed |
| WO-2003086394-A1 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | claimed |
| EP-1496896-A4 | INHIBITORS OF AKT ACTIVITY | MERCK & CO INC (US) | 2007-10-31 | — | — | EP | disclosed |
| EP-1496896-A1 | INHIBITORS OF AKT ACTIVITY | Merck & Co., Inc. (US) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003086394-A1 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | disclosed |