SCHEMBL5259184

SCHEMBL5259184

O=Cc1ccc(-c2ccc(-c3c[nH]c4ccccc34)cc2)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 1/20 0.60
IMPDH2 P12268 4/20 0.56
MAPK1 P28482 1/20 0.56
HSD17B10 Q99714 1/20 0.56
CYP2A6 P11509 1/20 0.51
TDO2 P48775 6/20 0.48
SIRT2 Q8IXJ6 2/20 0.47
SIRT1 Q96EB6 1/20 0.47
PRKD3 O94806 1/20 0.47
CCNB2 O95067 1/20 0.47
CCNE2 O96020 1/20 0.47
ABL1 P00519 1/20 0.47
PRKCG P05129 1/20 0.47
PRKCB P05771 1/20 0.47
CDK1 P06493 1/20 0.47
PIM1 P11309 1/20 0.47
CDK4 P11802 1/20 0.47
CCNB1 P14635 1/20 0.47
PRKCA P17252 1/20 0.47
PRKACA P17612 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28928045 0.98 NR4A2 (0.62) NR4A2IMPDH2MAPK1HSD17B10CYP2A6
SCHEMBL28416622 0.86 NR4A2 (0.78) NR4A2IMPDH2MAPK1HSD17B10TDO2
SCHEMBL28377762 0.84 NR4A2 (0.81) NR4A2IMPDH2MAPK1HSD17B10TDO2
SCHEMBL10227492 0.81 AXL (0.58) NR4A2IMPDH2MAPK1HSD17B10CYP2A6
SCHEMBL30030224 0.80 KIF11 (0.60) NR4A2IMPDH2MAPK1HSD17B10CYP2A6
SCHEMBL21232993 0.79 KIF11 (0.50) NR4A2IMPDH2MAPK1HSD17B10CYP2A6
SCHEMBL22158783 0.79 IMPDH2 (0.54) NR4A2IMPDH2MAPK1HSD17B10CYP2A6
3-Phenylindole SCHEMBL29609072 0.78 IMPDH2 (0.71) NR4A2IMPDH2MAPK1HSD17B10TDO2
3-Phenylindole SCHEMBL84056 0.78 IMPDH2 (0.71) NR4A2IMPDH2MAPK1HSD17B10TDO2
SCHEMBL16406546 0.77 PIK3CD (0.58) CYP2A6ABL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1844043-A2 HETEROCYCLE SUBSTITUTED CARBOXYLIC ACIDS FOR THE TREATMENT OF DIABETES The Institutes for Pharmaceutical Discovery, LLC (US) 2007-10-17 EP disclosed
EP-1836182-A2 HETEROCYCLYLBIPHENYL DERIVATES AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS The Institutes for Pharmaceutical Discovery, LLC (US) 2007-09-26 EP disclosed
WO-2006055708-A2 HETEROCYCLE SUBSTITUTED CARBOXYLIC ACIDS FOR THE TREATMENT OF DIABETES THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) 2006-05-26 WO disclosed
WO-2006055625-A2 HETEROCYCLYLBIPHENYL DERIVATES AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) 2006-05-26 WO disclosed
EP-1628970-A2 HETEROCYCLE SUBSTITUTED CARBOXYLIC ACIDS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B The Institutes of Pharmaceutical Discovery, LLC (US) 2006-03-01 EP disclosed
EP-1620422-A2 PHENYL SUBSTITUTED CARBOXYLIC ACIDS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B The Institutes for Pharmaceutical Discovery, LLC (US) 2006-02-01 EP disclosed
WO-2004099170-A2 PHENYL SUBSTITUTED CARBOXYLIC ACIDS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) 2004-11-18 WO disclosed
WO-2004099192-A2 HETEROCYCLE SUBSTITUTED CARBOXYLIC ACIDS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B THE INSTITUTES OF PHARMACEUTICAL DISCOVERY, LLC (US) 2004-11-18 WO disclosed