Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 15/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5259798 | 0.85 | CNR1 (0.50) | — | |
| SCHEMBL5259358 | 0.83 | CCNB2 (0.55) | VDRMAPTKDM4E | |
| SCHEMBL27574557 | 0.81 | CCNB2 (0.53) | VDRMAPTKDM4E | |
| SCHEMBL5259560 | 0.78 | VDR (0.47) | VDRMAPTTP53KDM1AMEN1 | |
| SCHEMBL5258148 | 0.75 | VDR (0.56) | VDRMAPTTP53KDM1AMEN1 | |
| SCHEMBL5256868 | 0.72 | VDR (0.48) | VDRMAPTTP53KDM1AMEN1 | |
| SCHEMBL5257153 | 0.72 | VDR (0.57) | VDRMAPTTP53KDM1AMEN1 | |
| SCHEMBL5258844 | 0.70 | VDR (0.55) | VDRMAPTTP53KDM1AMEN1 | |
| SCHEMBL8591132 | 0.70 | KDM1A (0.69) | VDRMAPTTP53KDM1AMEN1 | |
| SCHEMBL5258191 | 0.69 | VDR (0.54) | VDRMAPTKDM1AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261585-B1 | SUBSTITUTED INDOLE MANNICH BASES | GRUENENTHAL GMBH (DE) | 2007-09-26 | — | — | EP | claimed |
| US-7091220-B2 | Substituted indole Mannich bases | GRUENENTHAL GMBH (DE) | 2006-08-15 | — | — | US | claimed |
| CN-1219763-C | Substituted indole mannich bases | GRUENENTHAL GMBH (DE) | 2005-09-21 | — | — | CN | claimed |
| CN-1413192-A | Substituted indole mannich bases | GRUENENTHAL GMBH (DE) | 2003-04-23 | — | — | CN | claimed |
| EP-1261585-B1 | SUBSTITUTED INDOLE MANNICH BASES | GRUENENTHAL GMBH (DE) | 2007-09-26 | — | — | EP | disclosed |
| US-7091220-B2 | Substituted indole Mannich bases | GRUENENTHAL GMBH (DE) | 2006-08-15 | — | — | US | disclosed |
| CN-1219763-C | Substituted indole mannich bases | GRUENENTHAL GMBH (DE) | 2005-09-21 | — | — | CN | disclosed |
| CN-1413192-A | Substituted indole mannich bases | GRUENENTHAL GMBH (DE) | 2003-04-23 | — | — | CN | disclosed |
| US-20030060497-A1 | Subtituted indole mannich bases | GRUENENTHAL GMBH (DE) | 2003-03-27 | — | — | US | disclosed |
| EP-1261585-A1 | SUBSTITUTED INDOLE MANNICH BASES | Grünenthal GmbH (DE) | 2002-12-04 | — | — | EP | disclosed |
| WO-2001047882-A2 | SUBSTANCE LIBRARY WHICH CAN BE OBTAINED BY REACTING ALDEHYDES WITH SECONDARY AMINES, ACID CHLORIDES AND NAPHTHOL, PYRROLE AND/OR INDOLE COMPOUNDS | Grünenthal GmbH (DE) | 2001-07-05 | — | — | WO | disclosed |
| WO-2001047885-A1 | SUBSTITUTED INDOLE MANNICH BASES | Grünenthal GmbH (DE) | 2001-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030060497-A1 | Subtituted indole mannich bases | TPH1, IDO1, TPH2 | VDR 2170/4885MAPT 2635/4885TP53 1876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.