Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 12/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5258478 | 0.90 | KDM4E (0.47) | CHEK2ALDH1A1PRMT5KDM4E | |
| Trifluoroacetic Acid SCHEMBL4839422 | 0.87 | KDM4E (0.43) | CHEK2ALDH1A1PRMT5KDM4E | |
| SCHEMBL5256126 | 0.86 | CYP3A4 (0.47) | ALDH1A1KDM4E | |
| SCHEMBL4844677 | 0.86 | KDM4E (0.47) | CHEK2ALDH1A1KDM4ETBK1 | |
| Trifluoroacetic Acid SCHEMBL4844409 | 0.86 | ALDH1A1 (0.46) | CHEK2ALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL4834728 | 0.85 | CHEK2 (0.40) | CHEK2ALDH1A1HDAC3HDAC4HDAC1 | |
| Trifluoroacetic Acid SCHEMBL4843340 | 0.84 | CHEK2 (0.40) | CHEK2ALDH1A1HDAC3HDAC4HDAC1 | |
| SCHEMBL5259501 | 0.84 | KDM4E (0.36) | CHEK2ALDH1A1OPRK1HDAC3HDAC4 | |
| Trifluoroacetic Acid SCHEMBL4840418 | 0.80 | TBK1 (0.39) | CHEK2ALDH1A1KDM4ETBK1 | |
| SCHEMBL4841988 | 0.80 | SMN1; SMN2 (0.42) | CHEK2ALDH1A1PRMT5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539759-B1 | NOVEL IMIDAZOPYRIDINES AND THEIR USE | ASTRAZENECA AB (SE) | 2007-08-15 | — | — | EP | claimed |