Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.41 |
| ▸ | HRH2 | P25021 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5258478 | 0.95 | KDM4E (0.47) | KDM4EHSD17B10PRMT5CHEK2HRH2 | |
| Trifluoroacetic Acid SCHEMBL4846315 | 0.89 | CYP3A4 (0.43) | KDM4EHSD17B10PRMT5CHEK2ALDH1A1 | |
| SCHEMBL5260412 | 0.87 | CHEK2 (0.41) | KDM4EPRMT5CHEK2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL4844409 | 0.87 | ALDH1A1 (0.46) | KDM4ECHEK2ALDH1A1MEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL4843340 | 0.86 | CHEK2 (0.40) | KDM4ECHEK2ALDH1A1MEN1KMT2A | |
| SCHEMBL5259501 | 0.85 | KDM4E (0.36) | KDM4EHSD17B10CHEK2HRH2HRH1 | |
| SCHEMBL4841988 | 0.85 | SMN1; SMN2 (0.42) | KDM4EHSD17B10PRMT5CHEK2HRH2 | |
| Trifluoroacetic Acid SCHEMBL4840418 | 0.84 | TBK1 (0.39) | KDM4ECHEK2ALDH1A1MEN1KMT2A | |
| SCHEMBL4838134 | 0.83 | CYP3A4 (0.47) | KDM4EHSD17B10PRMT5ALDH1A1MEN1 | |
| Trifluoroacetic Acid SCHEMBL4837609 | 0.80 | TRPV3 (0.39) | CHEK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7410966-B2 | Use of and some novel imidazopyridines | ASTRAZENECA AB (SE) | 2008-08-12 | — | — | US | disclosed |
| EP-1539759-B1 | NOVEL IMIDAZOPYRIDINES AND THEIR USE | ASTRAZENECA AB (SE) | 2007-08-15 | — | — | EP | disclosed |
| US-20050261333-A1 | Use of and some novel imidazopyridines | ASTRAZENECA A B (SE) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261333-A1 | Use of and some novel imidazopyridines | ITK, CSNK1A1, RPS6KA1 | KDM4E 2903/4885HSD17B10 2866/4885PRMT5 707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.