Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.48 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14565693 | 0.90 | ALDH1A1 (0.50) | LMNAALDH1A1MAPTHPGDALOX15 | |
| SCHEMBL9835355 | 0.85 | PDE4B (0.55) | LMNAALDH1A1MAPTHPGDALOX15 | |
| SCHEMBL5262025 | 0.84 | CCNE2 (0.55) | LMNAALDH1A1MAPTHPGDALOX15 | |
| SCHEMBL9835965 | 0.82 | NR3C1 (0.60) | NR3C1 | |
| SCHEMBL587425 | 0.82 | PDE4B (0.60) | LMNAALDH1A1MAPTNR3C1ADORA1 | |
| SCHEMBL5257289 | 0.81 | LMNA (0.43) | LMNAALDH1A1MAPTHPGDALOX15 | |
| SCHEMBL2792459 | 0.79 | ALDH1A1 (0.49) | LMNAALDH1A1MAPTHPGDALOX15 | |
| SCHEMBL30644829 | 0.79 | ALDH1A1 (0.49) | LMNAALDH1A1MAPTHPGDALOX15 | |
| SCHEMBL9833323 | 0.79 | NR3C1 (0.53) | ALDH1A1NR3C1NPC1RAB9A | |
| SCHEMBL20176618 | 0.79 | LMNA (0.52) | LMNAALDH1A1MAPTHPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043998-B1 | USE OF PYRAZOLO [3,4-b] PYRIDINE AS CYCLIN DEPENDANT KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2007-03-07 | — | — | EP | disclosed |
| EP-1043998-B1 | USE OF PYRAZOLO [3,4-b] PYRIDINE AS CYCLIN DEPENDANT KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2007-03-07 | — | — | EP | disclosed |
| US-6107305-A | Use of pyrazolo [3,4-b] pyridine as cyclin dependent kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-08-22 | — | — | US | disclosed |