Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.47 |
| ▸ | TBK1 | Q9UHD2 | 7/20 | 0.45 |
| ▸ | ACHE | P22303 | 6/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | IKBKE | Q14164 | 4/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4837368 | 0.92 | HRH3 (0.52) | CHEK2TBK1ACHEHRH3IKBKE | |
| Trifluoroacetic Acid SCHEMBL4842116 | 0.91 | CHEK2 (0.53) | CHEK2TBK1ACHEIKBKECDK2 | |
| Trifluoroacetic Acid SCHEMBL4846269 | 0.90 | CHEK2 (0.44) | CHEK2TBK1ACHEIKBKECDK2 | |
| Trifluoroacetic Acid SCHEMBL5258099 | 0.88 | TBK1 (0.44) | CHEK2TBK1ACHEIKBKE | |
| SCHEMBL5260732 | 0.88 | ACHE (0.55) | CHEK2TBK1ACHEHRH3IKBKE | |
| Trifluoroacetic Acid SCHEMBL4840432 | 0.88 | LTA4H (0.47) | CHEK2TBK1ACHEIKBKECDK2 | |
| Trifluoroacetic Acid SCHEMBL4834494 | 0.87 | LTA4H (0.43) | CHEK2TBK1ACHEHRH3IKBKE | |
| Trifluoroacetic Acid SCHEMBL4841456 | 0.86 | CHEK2 (0.45) | CHEK2TBK1ACHEIKBKE | |
| Trifluoroacetic Acid SCHEMBL4843197 | 0.86 | TBK1 (0.51) | CHEK2TBK1ACHEIKBKE | |
| Trifluoroacetic Acid SCHEMBL4841636 | 0.86 | ACHE (0.53) | CHEK2TBK1ACHEIKBKEDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539759-B1 | NOVEL IMIDAZOPYRIDINES AND THEIR USE | ASTRAZENECA AB (SE) | 2007-08-15 | — | — | EP | disclosed |