SCHEMBL526115

SCHEMBL526115

O=C(Cl)Oc1cc2ccccc2s1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2L1 Q07817 1/20 0.50
HDAC3 O15379 1/20 0.47
HDAC4 P56524 1/20 0.47
HDAC1 Q13547 1/20 0.47
HDAC7 Q8WUI4 1/20 0.47
HDAC2 Q92769 1/20 0.47
HDAC10 Q969S8 1/20 0.47
HDAC11 Q96DB2 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
HDAC9 Q9UKV0 1/20 0.47
HDAC5 Q9UQL6 1/20 0.47
CYP2A6 P11509 3/20 0.47
CA2 P00918 2/20 0.46
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA4 P22748 1/20 0.46
CA5A P35218 1/20 0.46
CA7 P43166 1/20 0.46
CA9 Q16790 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2761209 0.83 BCL2L1 (0.56) BCL2L1HDAC3HDAC4HDAC1HDAC7
SCHEMBL29287403 0.83 BCL2L1 (0.52) BCL2L1HDAC3HDAC4HDAC1HDAC7
SCHEMBL9263208 0.81 SLC9A1 (0.50) BCL2L1HDAC3HDAC4HDAC1HDAC7
SCHEMBL4851399 0.81 BCL2L1 (0.50) BCL2L1HDAC3HDAC4HDAC1HDAC7
SCHEMBL5198179 0.79 HDAC3 (0.49) BCL2L1HDAC3HDAC4HDAC1HDAC7
SCHEMBL10951516 0.77 CYP2A6 (0.47) BCL2L1HDAC3HDAC4HDAC1HDAC7
SCHEMBL10929219 0.77 CYP2A6 (0.47) BCL2L1HDAC3HDAC4HDAC1HDAC7
SCHEMBL31544522 0.76 BCL2L1 (0.45) BCL2L1HDAC3HDAC4HDAC1HDAC7
SCHEMBL23751268 0.75 ALOX5 (0.47) BCL2L1HDAC3HDAC4HDAC1HDAC7
SCHEMBL9399940 0.75 ALOX5 (0.47) BCL2L1HDAC3HDAC4HDAC1HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2740476-B1 Cis-tetrahydro-spiro(cyclohexan-1,1'-pyrido[3,4-b]indol)-4-amine derivatives GRUENENTHAL GMBH (DE) 2018-12-05 EP disclosed
EP-2740476-A1 Cis-tetrahydro-spiro(cyclohexan-1,1'-pyrido[3,4-b]indol)-4-amine derivatives Grünenthal GmbH (DE) 2014-06-11 EP disclosed
EP-2598503-B1 CIS-TETRAHYDRO-SPIRO(CYCLOHEXAN-1,1'-PYRIDO[3,4-B]INDOL)-4-AMINE DERIVATIVES GRUENENTHAL GMBH (DE) 2014-03-26 EP disclosed
EP-2598503-A1 CIS-TETRAHYDROSPIRO(CYCLOHEXANE-1,1'-PYRIDO[3,4-B]INDOL)-4-AMINE DERIVATIVES Grünenthal GmbH (DE) 2013-06-05 EP disclosed
WO-2012013343-A1 CIS-TETRAHYDROSPIRO(CYCLOHEXANE-1,1'-PYRIDO[3,4-B]INDOL)-4-AMINE DERIVATIVES Grünenthal GmbH (DE) 2012-02-02 WO disclosed
EP-1246808-B1 1,2-DIARYL BENZIMIDAZOLES FOR TREATING ILLNESSES ASSOCIATED WITH A MICROGLIA ACTIVATION BAYER SCHERING PHARMA AG (DE) 2011-08-17 EP disclosed
EP-1025086-B1 BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS MERCK PATENT GMBH (DE) 2003-06-25 EP disclosed
EP-1246808-A1 1,2-DIARYL BENZIMIDAZOLES FOR TREATING ILLNESSES ASSOCIATED WITH A MICROGLIA ACTIVATION SCHERING AKTIENGESELLSCHAFT (DE) 2002-10-09 EP disclosed
WO-2001051473-A1 1,2-DIARYL BENZIMIDAZOLES FOR TREATING ILLNESSES ASSOCIATED WITH A MICROGLIA ACTIVATION SCHERING AKTIENGESELLSCHAFT (DE) 2001-07-19 WO disclosed
WO-1998045283-A1 MICROBICIDAL BENZOTHIOPHENE S-OXIDE DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 1998-10-15 WO disclosed
EP-0699193-A1 CARBOXYLIC ACID AMIDE BENZOTHIOPHENE-S-OXIDES BAYER AG (DE) 1996-03-06 EP disclosed
EP-0512349-B1 Benzothiophene-2-carboxamide-S,S-dioxides BAYER AG (DE) 1996-02-14 EP disclosed
WO-1994027986-A1 CARBOXYLIC ACID AMIDE BENZOTHIOPHENE-S-OXIDES BAYER AKTIENGESELLSCHAFT (DE) 1994-12-08 WO disclosed
EP-0512349-A1 Benzothiophene-2-carboxamide-S,S-dioxides BAYER AG (DE) 1992-11-11 EP disclosed
US-4514399-A N-N'substituted polymethylene diamines ADIR (FR) 1985-04-30 US disclosed