Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.43 |
| ▸ | LIPE | Q05469 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5261641 | 0.76 | SCN9A (0.42) | LMNASCN9ALIPEMAPK1 | |
| SCHEMBL3549808 | 0.72 | PLAAT3 (0.47) | LMNASCN9ALIPERAB9ADAGLA | |
| SCHEMBL8410599 | 0.72 | LMNA (0.48) | LMNALIPERAB9ADAGLA | |
| SCHEMBL3540389 | 0.71 | PLAAT3 (0.52) | LMNASCN9ALIPERAB9ADAGLA | |
| SCHEMBL8410794 | 0.69 | LMNA (0.47) | LMNASCN9ALIPEMAPK1DAGLA | |
| SCHEMBL15684926 | 0.69 | LMNA (0.43) | LMNASCN9ALIPEMAPK1 | |
| SCHEMBL15684946 | 0.69 | MAPK1 (0.42) | LMNASCN9ALIPERAB9AMAPK1 | |
| SCHEMBL15132941 | 0.68 | LMNA (0.59) | LMNASCN9ALIPERAB9AMAPK1 | |
| SCHEMBL8410697 | 0.68 | LIPE (0.45) | LMNASCN9ALIPERAB9AMAPK1 | |
| SCHEMBL9255996 | 0.67 | MAPK1 (0.74) | LMNASCN9ALIPERAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856053-A1 | CINNAMIDE AND HYDROCINNAMIDE DERIVATIVES WITH RAF-KINASE INHIBITORY ACTIVITY | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006076706-A1 | CINNAMIDE AND HYDROCINNAMIDE DERIVATIVES WITH RAF-KINASE INHIBITORY ACTIVITY | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-07-20 | — | — | WO | claimed |