SCHEMBL8410697

SCHEMBL8410697

C#CCN(C(=O)Cc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1)c1ccnc(CC)c1Cl

nearest known ligand 0.46

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
LIPE Q05469 10/20 0.45
DAGLA Q9Y4D2 1/20 0.41
LMNA P02545 2/20 0.41
SCN9A Q15858 3/20 0.38
MAPK1 P28482 1/20 0.38
RAB9A P51151 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8410794 0.84 LMNA (0.47) LIPEDAGLALMNASCN9AMAPK1
SCHEMBL8411835 0.80 LIPE (0.43) LIPEDAGLALMNASCN9A
SCHEMBL8410599 0.77 LMNA (0.48) LIPEDAGLALMNARAB9A
SCHEMBL3549808 0.72 PLAAT3 (0.47) LIPEDAGLALMNASCN9ARAB9A
SCHEMBL15684814 0.72 LMNA (0.48) LIPEDAGLALMNARAB9A
SCHEMBL3540389 0.71 PLAAT3 (0.52) LIPEDAGLALMNASCN9ARAB9A
SCHEMBL9304488 0.70 LMNA (0.58) LIPELMNASCN9AMAPK1RAB9A
SCHEMBL9267594 0.70 LMNA (0.63) LIPELMNAMAPK1RAB9A
SCHEMBL8410496 0.70 LMNA (0.60) LIPEDAGLALMNARAB9A
SCHEMBL15684767 0.70 LIPE (0.44) LIPEDAGLALMNASCN9AMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0822930-B1 PYRIDINE DERIVATIVE AND PESTICIDE KUMIAI CHEMICAL INDUSTRY CO (JP) 1999-07-28 EP disclosed
US-5763463-A Pyridine compounds which are useful as pesticides KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1998-06-09 US disclosed