Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 5/20 | 0.39 |
| ▸ | AKT2 | P31751 | 4/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6102455 | 0.87 | AKT1 (0.49) | AKT1AKT2MAPK14ALDH1A1KDM4E | |
| SCHEMBL5264075 | 0.86 | ROCK2 (0.42) | AKT1AKT2ALDH1A1KDM4EMAPK1 | |
| SCHEMBL5263570 | 0.85 | MAPK14 (0.39) | AKT1AKT2MAPK14ALDH1A1KDM4E | |
| SCHEMBL5261876 | 0.85 | ALDH1A1 (0.41) | AKT1AKT2MAPK14ALDH1A1KDM4E | |
| SCHEMBL5264566 | 0.85 | PTGS2 (0.52) | MAPK14ALDH1A1PTGS2PTGS1 | |
| SCHEMBL5263130 | 0.82 | AKT1 (0.43) | AKT1AKT2MAPK14ALDH1A1KDM4E | |
| SCHEMBL5264263 | 0.80 | MAPK14 (0.50) | AKT1AKT2MAPK14PTGS2PTGS1 | |
| SCHEMBL5261444 | 0.78 | MAPK14 (0.42) | AKT1AKT2MAPK14MAPK13MAPK12 | |
| SCHEMBL5265058 | 0.78 | AKT1 (0.49) | AKT1AKT2MAPK14KDM4EMAPK13 | |
| SCHEMBL5263424 | 0.78 | AKT1 (0.40) | AKT1AKT2MAPK14ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660500-B1 | SUBSTITUTED IMIDAZOPYRIMIDINES FOR THE PREVENTION AND TREATMENT OF CANCER | S A L V A T LAB SA (ES) | 2007-12-12 | — | — | EP | disclosed |
| US-20060189631-A1 | Substituted imidazopyrimidines for the prevention and treatment of cancer | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2006-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060189631-A1 | Substituted imidazopyrimidines for the prevention and treatment of cancer | BRCA1, CCNA1, DPYD | AKT1 3579/4885AKT2 3297/4885MAPK14 3719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.