Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 11/20 | 0.49 |
| ▸ | AKT2 | P31751 | 10/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5263570 | 0.90 | MAPK14 (0.39) | AKT1AKT2MAPK14KDM4EALDH1A1 | |
| SCHEMBL5264566 | 0.87 | PTGS2 (0.52) | MAPK14ALDH1A1 | |
| SCHEMBL5261869 | 0.87 | AKT1 (0.39) | AKT1AKT2MAPK14KDM4EALDH1A1 | |
| SCHEMBL23407549 | 0.78 | KLK7 (0.46) | AKT1AKT2MAPK14ROCK2PIM1 | |
| SCHEMBL29620846 | 0.78 | KLK7 (0.46) | AKT1AKT2MAPK14ROCK2PIM1 | |
| SCHEMBL5260161 | 0.78 | MAPT (0.45) | AKT1AKT2MAPK14ROCK2PIM1 | |
| SCHEMBL5260974 | 0.75 | PTGS2 (0.52) | AKT1AKT2ROCK2PIM1GSK3B | |
| SCHEMBL5264075 | 0.75 | ROCK2 (0.42) | AKT1AKT2ROCK2PIM1GSK3B | |
| SCHEMBL5262641 | 0.73 | ALDH1A1 (0.47) | AKT1AKT2MAPK14KDM4EALDH1A1 | |
| SCHEMBL5265821 | 0.73 | AKT1 (0.48) | AKT1AKT2MAPK14ROCK2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060189631-A1 | Substituted imidazopyrimidines for the prevention and treatment of cancer | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2006-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060189631-A1 | Substituted imidazopyrimidines for the prevention and treatment of cancer | BRCA1, CCNA1, DPYD | AKT1 3579/4885AKT2 3297/4885MAPK14 3719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.