Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14621420 | 0.90 | HSPB1 (0.48) | HSPB1MAPTPIN1KDM4ESCN9A | |
| SCHEMBL11942099 | 0.82 | HSPB1 (0.42) | HSPB1MAPTPIN1TDP1L3MBTL1 | |
| SCHEMBL5258681 | 0.81 | HSPB1 (0.45) | HSPB1MAPTKDM4ESCN9AALDH1A1 | |
| SCHEMBL4851442 | 0.81 | TDP1 (0.65) | HSPB1MAPTTDP1L3MBTL1ATM | |
| SCHEMBL15770914 | 0.79 | HSPB1 (0.51) | HSPB1MAPTTDP1L3MBTL1ATM | |
| SCHEMBL16692791 | 0.78 | POLB (0.44) | MAPTTDP1KDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL29043661 | 0.78 | ALDH1A1 (0.48) | MAPTPIN1TDP1ALDH1A1HPGD | |
| SCHEMBL31371566 | 0.77 | HSPB1 (0.52) | HSPB1MAPTTDP1L3MBTL1ATM | |
| SCHEMBL28402286 | 0.76 | PDGFRB (0.45) | MAPTTDP1KDM4EALDH1A1HPGD | |
| SCHEMBL15067957 | 0.75 | HSPB1 (0.47) | HSPB1MAPTTDP1L3MBTL1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070135459-A1 | Substituted 7-aza-quinazoline compounds useful as p38 kinase inhibitors | DEWDNEY NOLAN J | 2007-06-14 | — | — | US | disclosed |
| US-20070135459-A1 | Substituted 7-aza-quinazoline compounds useful as p38 kinase inhibitors | DEWDNEY NOLAN J | 2007-06-14 | — | — | US | disclosed |
| US-7189731-B2 | Substituted 7-azaquinazoline compounds useful as p38 kinase inhibitors | ROCHE PALO ALTO LLC (US) | 2007-03-13 | — | — | US | disclosed |
| US-7189731-B2 | Substituted 7-azaquinazoline compounds useful as p38 kinase inhibitors | ROCHE PALO ALTO LLC (US) | 2007-03-13 | — | — | US | disclosed |
| EP-1620105-B1 | (6-(PHENOXY)-PYRIDO¬3,4-D|PYRIMIDIN-2-YL)-AMINE DERIVATIVES AS P38 KINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY CONDITIONS SUCH AS RHEUMATOID ARTHRITIS | HOFFMANN LA ROCHE (CH) | 2007-01-10 | — | — | EP | disclosed |
| EP-1620105-A1 | (6-(PHENOXY)-PYRIDO[3,4-D]PYRIMIDIN-2-YL)-AMINE DERIVATIVES AS P38 KINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY CONDITIONS SUCH AS RHEUMATOID ARTHRITIS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004091625-A1 | (6-(PHENOXY)-PYRIDO`3,4-D! PYRIMIDIN-2-YL)-AMINE DERIVATIVES AS P38 KINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORYY CONDITIONS SUCH AS RHEUMATOIS ARTRITIS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-10-28 | — | — | WO | disclosed |
| US-20040209903-A1 | Substituted 7-azaquinazoline compounds useful as p38 kinase inhibitors | ROCHE PALO ALTO LLC | 2004-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135459-A1 | Substituted 7-aza-quinazoline compounds useful as p38 kinase inhibitors | MAPK7, MAPK1, MAPK8 | HSPB1 2421/4885MAPT 4184/4885PIN1 3179/4885 |
| US-20040209903-A1 | Substituted 7-azaquinazoline compounds useful as p38 kinase inhibitors | MAPK1, MAPK7, MAPK6 | HSPB1 1468/4885MAPT 4240/4885PIN1 3070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.