Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPD | P32754 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4434450 | 0.89 | TACR1 (0.38) | MAPTALDH1A1MEN1KMT2ATACR1 | |
| SCHEMBL5262268 | 0.88 | MAPT (0.40) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL4445337 | 0.88 | MAPT (0.40) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL4433895 | 0.88 | KDM4E (0.39) | ALDH1A1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL4444516 | 0.87 | MAPK1 (0.40) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL4437157 | 0.86 | HCAR3 (0.39) | MAPTMEN1KMT2AMAPK1CYP1A2 | |
| SCHEMBL4439400 | 0.86 | POLB (0.40) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL4445145 | 0.85 | CYP2C9 (0.41) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL4434940 | 0.84 | MEN1 (0.39) | MAPTMEN1KMT2ACYP2D6LMNA | |
| SCHEMBL4438391 | 0.84 | KMT2A (0.36) | MAPTALDH1A1KMT2AMAPK1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |