Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.40 |
| ▸ | CHRNG | P07510 | 1/20 | 0.40 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7783953 | 0.85 | ALDH1A1 (0.42) | MTNR1AMTNR1BALDH1A1HTR2CSMN1; SMN2 | |
| SCHEMBL4438550 | 0.84 | MTNR1A (0.44) | MTNR1AMTNR1BALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2176096 | 0.84 | MTNR1A (0.41) | MTNR1AMTNR1BALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2173334 | 0.81 | MTNR1A (0.44) | MTNR1AMTNR1BALDH1A1SMN1; SMN2PTGES | |
| SCHEMBL7703944 | 0.80 | MTNR1A (0.40) | MTNR1AMTNR1BALDH1A1HTR2CSMN1; SMN2 | |
| SCHEMBL3933066 | 0.79 | HTR2C (0.47) | ALDH1A1HTR2CSMN1; SMN2LMNATP53 | |
| SCHEMBL16934132 | 0.79 | ALDH1A1 (0.47) | ALDH1A1HTR2CSMN1; SMN2LMNATP53 | |
| SCHEMBL2850199 | 0.79 | HTR2C (0.47) | ALDH1A1HTR2CSMN1; SMN2LMNATP53 | |
| SCHEMBL578453 | 0.79 | ALDH1A1 (0.47) | ALDH1A1HTR2CSMN1; SMN2LMNATP53 | |
| SCHEMBL2543696 | 0.79 | ALDH1A1 (0.63) | ALDH1A1HTR2CSMN1; SMN2LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794135-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006037117-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | disclosed |