SCHEMBL4438550

SCHEMBL4438550

CC(CO)N(C(=O)O)c1cccc(Br)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 2/20 0.44
MTNR1B P49286 2/20 0.44
PTGES O14684 1/20 0.43
ALDH1A1 P00352 4/20 0.40
SMN1; SMN2 Q16637 4/20 0.39
HTT P42858 1/20 0.39
L3MBTL1 Q9Y468 2/20 0.38
PARP1 P09874 1/20 0.38
HSD17B10 Q99714 1/20 0.37
LMNA P02545 2/20 0.37
KDM4E B2RXH2 1/20 0.37
NPC1 O15118 1/20 0.37
CASP3 P42574 1/20 0.37
RAB9A P51151 1/20 0.37
SENP8 Q96LD8 1/20 0.37
SENP7 Q9BQF6 1/20 0.37
SENP6 Q9GZR1 1/20 0.37
MRGPRX4 Q96LA9 1/20 0.37
CHRNA1 P02708 1/20 0.37
CHRNG P07510 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2173334 0.84 MTNR1A (0.44) MTNR1AMTNR1BPTGESALDH1A1SMN1; SMN2
SCHEMBL5262282 0.84 MTNR1A (0.44) MTNR1AMTNR1BPTGESALDH1A1SMN1; SMN2
SCHEMBL14796731 0.82 CYP2B6 (0.41) ALDH1A1SMN1; SMN2LMNANPC1TP53
SCHEMBL2173909 0.81 MTNR1A (0.41) MTNR1AMTNR1BPTGESALDH1A1SMN1; SMN2
SCHEMBL2171679 0.81 AAK1 (0.38) MTNR1AMTNR1BSMN1; SMN2L3MBTL1LMNA
SCHEMBL2176096 0.79 MTNR1A (0.41) MTNR1AMTNR1BPTGESALDH1A1SMN1; SMN2
SCHEMBL18185124 0.74 PSEN1 (0.39) PTGESALDH1A1SMN1; SMN2L3MBTL1LMNA
SCHEMBL7783953 0.73 ALDH1A1 (0.42) MTNR1AMTNR1BPTGESALDH1A1SMN1; SMN2
SCHEMBL14229073 0.72 L3MBTL1 (0.41) MTNR1AMTNR1BALDH1A1SMN1; SMN2HTT
SCHEMBL1400933 0.72 MTNR1A (0.48) MTNR1AMTNR1BPTGESALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2097387-A2 HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS SCHERING CORPORATION (US) 2009-09-09 EP disclosed
WO-2008103351-A2 HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS SCHERING CORPORATION (US) 2008-08-28 WO disclosed
EP-1838304-A2 HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS SCHERING CORPORATION (US) 2007-10-03 EP disclosed
WO-2006065277-A2 HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS SCHERING CORPORATION (US) 2006-06-22 WO disclosed