Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | FABP3 | P05413 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 3/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5262920 | 0.69 | KDM4E (0.40) | ACP1FAAHFABP3FABP4FABP5 | |
| SCHEMBL7017610 | 0.69 | KMO (0.42) | FAAHPPARA | |
| SCHEMBL4075582 | 0.68 | CYP2D6 (0.37) | FAAHCYP2A6HTTLMNACYP1A2 | |
| SCHEMBL28446740 | 0.65 | HSP90AA1 (0.46) | HTR3AHRH4KDM4EHTTSMN1; SMN2 | |
| SCHEMBL6415649 | 0.64 | CCNC (0.46) | FAAHKDM4ELMNAEGFRSMN1; SMN2 | |
| SCHEMBL8889345 | 0.63 | MAPK1 (0.54) | CYP2A6KDM4EHTTL3MBTL1CYP1A2 | |
| SCHEMBL740617 | 0.63 | MGAM (0.56) | HTR3AHRH4KDM4ELMNAL3MBTL1 | |
| SCHEMBL11282482 | 0.62 | AKR1B1 (0.47) | KDM4EHTTLMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL28433205 | 0.62 | SMN1; SMN2 (0.70) | FAAHHTTCYP1A2SMN1; SMN2NPC1 | |
| SCHEMBL11435568 | 0.62 | ALDH1A1 (0.52) | KDM4ELMNACYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824817-A1 | ARYLSULFONYLNAPHTHALENE DERIVATIVES AS 5HT2A ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006059149-A1 | ARYLSULFONYLNAPHTHALENE DERIVATIVES AS 5HT2A ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 2006-06-08 | — | — | WO | disclosed |