Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.39 |
| ▸ | FOS | P01100 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27438770 | 0.79 | ALOX5 (0.49) | CYP3A4TSHRMAPK1ALOX5CYP1A2 | |
| SCHEMBL6935416 | 0.77 | CYP3A4 (0.42) | ALOX15ALOX12NR3C1HSD17B2CYP3A4 | |
| SCHEMBL25331583 | 0.77 | HSD17B2 (0.41) | ALOX15ALOX12FOSTTRJUN | |
| SCHEMBL20348822 | 0.74 | PDE4D (0.45) | PDE4DALOX15ALOX12CYP3A4MAPK1 | |
| SCHEMBL16625547 | 0.72 | ALDH1A1 (0.56) | CYP3A4ALOX5MEN1POLBKMT2A | |
| SCHEMBL30978325 | 0.72 | CYP3A4 (0.41) | ALOX15ALOX12FOSTTRJUN | |
| SCHEMBL5514890 | 0.72 | MAPT (0.44) | NFKB1ALOX5NFKB2RELACYP1A2 | |
| SCHEMBL8293517 | 0.71 | CYP3A4 (0.65) | ALOX15ALOX12CYP3A4TSHRADRB2 | |
| SCHEMBL8294109 | 0.71 | TAAR1 (0.67) | ALOX15ALOX12FOSTTRJUN | |
| SCHEMBL9719955 | 0.71 | ADRB2 (0.54) | ALOX15ALOX12FOSTTRJUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836183-A2 | SPIRO DERIVATIVES AS LIPOXYGENASE INHIBITORS | Galileo Pharmaceuticals, Inc. (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006065686-A2 | SPIRO DERIVATIVES AS LIPOXYGENASE INHIBITORS | GALILEO PHARMACEUTICALS, INC. (US) | 2006-06-22 | — | — | WO | disclosed |