Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | PER2 | O15055 | 1/20 | 0.41 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.41 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14632372 | 0.77 | KCNN4 (0.42) | GSK3BKCNN4KCNA5GPR139ADAMTS4 | |
| SCHEMBL16934132 | 0.76 | ALDH1A1 (0.47) | HTR2CLMNAALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL14697483 | 0.76 | KCNA5 (0.46) | GSK3BKCNN4KCNA5LMNAALDH1A1 | |
| SCHEMBL2850199 | 0.76 | HTR2C (0.47) | HTR2CLMNAALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL3933066 | 0.76 | HTR2C (0.47) | HTR2CLMNAALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL578453 | 0.76 | ALDH1A1 (0.47) | HTR2CLMNAALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL5262282 | 0.76 | MTNR1A (0.44) | HTR2CLMNAALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL6300638 | 0.76 | FFAR1 (0.47) | GSK3BKCNN4KCNA5LMNAALDH1A1 | |
| SCHEMBL13367360 | 0.76 | KCNA5 (0.46) | KCNN4KCNA5GPR139PER2CRY1 | |
| SCHEMBL2543696 | 0.75 | ALDH1A1 (0.63) | HTR2CLMNAALDH1A1TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794135-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006037117-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | disclosed |