Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | CDK4 | P11802 | 4/20 | 0.66 |
| ▸ | CCND1 | P24385 | 4/20 | 0.66 |
| ▸ | KMO | O15229 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | TERT | O14746 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.53 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29684637 | 1.00 | LMNA (0.73) | LMNAKMT2ACDK4CCND1KMO | |
| SCHEMBL29560163 | 0.90 | CDK4 (0.68) | LMNAKMT2ACDK4CCND1KMO | |
| SCHEMBL1967792 | 0.90 | CDK4 (0.68) | LMNAKMT2ACDK4CCND1KMO | |
| SCHEMBL1269116 | 0.88 | CDK4 (0.71) | LMNAKMT2ACDK4CCND1MAPK1 | |
| SCHEMBL19783673 | 0.87 | CDK4 (0.72) | LMNAKMT2ACDK4CCND1MAPK1 | |
| SCHEMBL30582936 | 0.87 | CDK4 (0.72) | LMNAKMT2ACDK4CCND1MAPK1 | |
| SCHEMBL12881191 | 0.84 | LMNA (0.71) | LMNAKMT2ACDK4CCND1MAPK1 | |
| SCHEMBL7349228 | 0.84 | LMNA (1.00) | LMNAKMT2ACDK4CCND1MAPK1 | |
| SCHEMBL10203635 | 0.83 | LMNA (0.69) | LMNAKMT2ACDK4CCND1MAPK1 | |
| SCHEMBL31370177 | 0.82 | MAPK1 (0.62) | LMNAKMT2ACDK4CCND1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114456699-A | Seawater alternation resistant marine antifouling paint and preparation method thereof | 嘉兴学院 | 2022-05-10 | — | — | CN | claimed |
| EP-2509424-A1 | NOVEL OXADIAZOLE COMPOUNDS | Abbott Laboratories (US) | 2012-10-17 | — | — | EP | claimed |
| WO-2011071570-A1 | NOVEL OXADIAZOLE COMPOUNDS | ABBOTT LABORATORIES (US) | 2011-06-16 | — | — | WO | claimed |
| EP-0715627-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | Pfizer Limited (GB) | 1996-06-12 | — | — | EP | claimed |
| WO-1995006046-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | PFIZER LIMITED (GB) | 1995-03-02 | — | — | WO | claimed |
| CN-116496200-B | Lysosome/mitochondrion bicolor fluorescent probe with pH responsiveness and preparation method and application thereof | 中山大学 | 2024-07-05 | — | — | CN | disclosed |
| US-20230339934-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | RAQUALIA PHARMA INC. (JP) | 2023-10-26 | — | — | US | disclosed |
| US-20230339934-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | RAQUALIA PHARMA INC. (JP) | 2023-10-26 | — | — | US | disclosed |
| EP-3625316-B1 | DISPERSANTS, METHOD OF MAKING, AND USING SAME | CHEVRON ORONITE CO (US) | 2023-08-23 | — | — | EP | disclosed |
| CN-116496200-A | Lysosome/mitochondrion bicolor fluorescent probe with pH responsiveness and preparation method and application thereof | 中山大学 | 2023-07-28 | — | — | CN | disclosed |
| US-11583517-B2 | Dual antagonist of PGD2/DPr2 and Thromboxane A2/TPr receptors and use for treatment of maladaptive immune response or thrombotic diathesis | APPLIED MEDICAL TECHNOLOGIES LLC (US) | 2023-02-21 | — | — | US | disclosed |
| EP-4126050-A1 | DUAL ANTAGONIST OF PGD2/DPR2 AND THROMBOXANE A2/TPR RECEPTORS AND USE FOR TREATMENT OF MALAPTIVE IMMUNE RESPONSE OR THROMBOTIC DIATHESIS | Applied Medical Technologies LLC (US) | 2023-02-08 | — | — | EP | disclosed |
| WO-1997034922-A1 | TREATMENT OF PREECLAMPSIA, ECLAMPSIA OR PRETERM LABOR WITH CALCITONIN GENE RELATED PEPTIDE AND RELATED DRUGS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1997-09-25 | — | — | WO | disclosed |
| EP-0715627-A1 | INDOLE DERIVATIVES AS THROMBOXANE A2 ANTAGONISTS | Pfizer Limited (GB) | 1996-06-12 | — | — | EP | disclosed |
| EP-0708647-A1 | COMBINATION OF A PROGESTATIONAL AGENT AND A NITRIC OXIDE SYNTHASE SUBSTRATE AND/OR DONOR FOR THE TREATMENT OF PREECLAMPSIA AND PRETERM LABOR | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-05-01 | — | — | EP | disclosed |
| US-5389661-A | Treats hypertension, heart failure, glaucoma and hyperaldosteronism | WARNER-LAMBERT COMPANY (US) | 1995-02-14 | — | — | US | disclosed |
| WO-1995002408-A1 | COMBINATION OF A PROGESTATIONAL AGENT AND A NITRIC OXIDE SYNTHASE SUBSTRATE AND/OR DONOR FOR THE TREATMENT OF PREECLAMPSIA AND PRETERM LABOR | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-01-26 | — | — | WO | disclosed |
| US-5322950-A | Treating hypertension, hyperaldosteronism, glaucoma, heart failure | WARNER-LAMBERT COMPANY (US) | 1994-06-21 | — | — | US | disclosed |
| WO-1994011361-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | THE UPJOHN COMPANY (US) | 1994-05-26 | — | — | WO | disclosed |
| US-4273782-A | FOR USE IN CARDIOVASCULAR DISORDERS AND COMPLICATIONS OF DIABETES | PFIZER INC. (US) | 1981-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230339934-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | TRPV4, TRPV1, TRPV2 | LMNA 4199/4885KMT2A 4196/4885CDK4 408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.