Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27806504 | 0.84 | TSHR (0.41) | TSHRLMNAL3MBTL1TDP1ALDH1A1 | |
| SCHEMBL21382113 | 0.83 | ALDH1A1 (0.47) | TSHRLMNAL3MBTL1TDP1ALDH1A1 | |
| SCHEMBL27955327 | 0.81 | ALDH1A1 (0.48) | TSHRLMNAL3MBTL1ALDH1A1RAB9A | |
| SCHEMBL27938388 | 0.80 | MAPT (0.48) | TSHRLMNAL3MBTL1ALDH1A1RAB9A | |
| SCHEMBL1600710 | 0.78 | HDAC8 (0.41) | TSHRLMNAL3MBTL1ALDH1A1RAB9A | |
| SCHEMBL4448680 | 0.78 | APP (0.49) | TSHRLMNAL3MBTL1TDP1ALDH1A1 | |
| SCHEMBL2083223 | 0.76 | MTNR1A (0.48) | TSHRLMNAL3MBTL1ALDH1A1RAB9A | |
| SCHEMBL15320269 | 0.76 | TSHR (0.50) | TSHRLMNAL3MBTL1ALDH1A1RAB9A | |
| SCHEMBL4439906 | 0.76 | LMNA (0.38) | TSHRLMNAL3MBTL1TDP1ALDH1A1 | |
| SCHEMBL5737663 | 0.76 | TSHR (0.55) | TSHRLMNAL3MBTL1TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794135-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006037117-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | disclosed |