Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5970515 | 0.85 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPK1ALDH1A1TSHRHPGD | |
| SCHEMBL21728172 | 0.83 | ACHE (0.54) | SSTR4SMN1; SMN2MAPK1ACHEALDH1A1 | |
| SCHEMBL11139550 | 0.78 | POLB (0.46) | ACHEALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL1432109 | 0.75 | KMT2A (0.41) | SMN1; SMN2MAPK1ACHEALDH1A1TSHR | |
| SCHEMBL4595414 | 0.74 | ALDH1A1 (0.43) | ALDH1A1HPGDNPC1RAB9AGAA | |
| SCHEMBL4119375 | 0.73 | POLB (0.50) | SMN1; SMN2ACHEALDH1A1TSHRGAA | |
| SCHEMBL1959471 | 0.72 | ERN1 (0.53) | SMN1; SMN2ACHEALDH1A1TSHRHPGD | |
| SCHEMBL22172091 | 0.72 | TSHR (0.43) | SSTR4SMN1; SMN2MAPK1ACHEALDH1A1 | |
| SCHEMBL30957147 | 0.71 | TSHR (0.44) | SSTR4SMN1; SMN2MAPK1ALDH1A1TSHR | |
| SCHEMBL5636872 | 0.70 | TSHR (0.42) | SSTR4SMN1; SMN2MAPK1ACHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740551-A1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF AS AN MMP-13 INHIBITOR | Takeda Pharmaceutical Company Limited (JP) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005105760-A1 | HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF AS AN MMP-13 INHIBITOR | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-11-10 | — | — | WO | disclosed |