Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 4/20 | 0.58 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | TTK | P33981 | 4/20 | 0.41 |
| ▸ | LIPC | P11150 | 1/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3998287 | 0.89 | KDM4E (0.54) | CREBBPBRD4TTKNPC1PTGER4 | |
| SCHEMBL3995887 | 0.85 | CREBBP (0.43) | CREBBPLIPCLIPG | |
| SCHEMBL1608768 | 0.83 | CREBBP (0.44) | CREBBPBRD4KDM4E | |
| SCHEMBL3997595 | 0.82 | ALDH1A1 (0.48) | CREBBPBRD4NPC1PDK1PDK2 | |
| SCHEMBL23978061 | 0.76 | HCAR3 (0.70) | HCAR3NPC1MEN1KMT2A | |
| SCHEMBL4003424 | 0.75 | LIPC (0.43) | CREBBPLIPCLIPGNPC1PTGER4 | |
| SCHEMBL28613837 | 0.74 | CREBBP (1.00) | CREBBP | |
| SCHEMBL13605696 | 0.74 | HDAC3 (0.39) | CREBBPTTKNPC1MEN1KMT2A | |
| SCHEMBL1609240 | 0.73 | CNR2 (0.44) | CREBBPBRD4MEN1KMT2A | |
| SCHEMBL30394441 | 0.73 | KCNH3 (0.46) | CREBBPHCAR3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809607-A1 | SULFONYL BENZIMIDAZOLE DERIVATIVES | Pfizer, Inc. (US) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006048754-A1 | SULFONYL BENZIMIDAZOLE DERIVATIVES | PFIZER JAPAN INC. (JP) | 2006-05-11 | — | — | WO | disclosed |