SCHEMBL5264223

SCHEMBL5264223

CCN(C(=O)OC(C)(C)C)c1ccc(CCN)cc1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
AOC3 Q16853 2/20 0.41
TAAR1 Q96RJ0 4/20 0.40
ACHE P22303 2/20 0.39
MLYCD O95822 1/20 0.39
TSHR P16473 2/20 0.38
HTT P42858 1/20 0.36
ALDH1A1 P00352 2/20 0.36
BACE1 P56817 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2A6 P11509 1/20 0.36
KDM4E B2RXH2 1/20 0.36
HTR1A P08908 1/20 0.36
ADRA2A P08913 1/20 0.36
SLC6A2 P23975 1/20 0.36
CYP2C19 P33261 1/20 0.36
HTR3A P46098 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
HTR2A P28223 1/20 0.36
GLA P06280 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4738587 0.85 TSHR (0.43) ACHEMLYCDTSHRHTTALDH1A1
SCHEMBL4840795 0.84 PPARG (0.41) MLYCDTSHRHTTALDH1A1KDM4E
SCHEMBL3894800 0.80 TSHR (0.42) MLYCDTSHRHTTALDH1A1KDM4E
SCHEMBL2552511 0.79 TSHR (0.41) MLYCDTSHRHTTALDH1A1KDM4E
SCHEMBL572741 0.79 ALDH1A1 (0.59) TSHRHTTALDH1A1CYP2C19GLA
SCHEMBL4838461 0.78 ALDH1A1 (0.47) MLYCDTSHRHTTALDH1A1CYP2A6
SCHEMBL12719411 0.78 ALDH1A1 (0.42) TSHRHTTALDH1A1GLA
SCHEMBL2312956 0.77 LMNA (0.39) AOC3TAAR1ACHEALDH1A1BACE1
SCHEMBL16640701 0.77 NR1H4 (0.38)
SCHEMBL2318201 0.77 ACHE (0.41) TAAR1ACHEHTTALDH1A1BACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1794135-A1 SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE Amgen Inc. (US) 2007-06-13 EP disclosed
WO-2006037117-A1 SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE AMGEN INC. (US) 2006-04-06 WO disclosed