SCHEMBL526434

SCHEMBL526434

Oc1ccc(C(Cl)(Cl)Cl)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 10/20 0.52
ESR2 Q92731 10/20 0.52
CYP3A4 P08684 3/20 0.52
TSHR P16473 3/20 0.52
LMNA P02545 2/20 0.52
TYR P14679 2/20 0.52
HPGD P15428 2/20 0.52
HSD17B10 Q99714 2/20 0.52
AR P10275 1/20 0.52
SLC6A2 P23975 1/20 0.52
SLC6A4 P31645 1/20 0.52
HTR6 P50406 1/20 0.52
ESRRG P62508 1/20 0.52
SLC6A3 Q01959 1/20 0.52
ALDH1A1 P00352 2/20 0.50
KDM4E B2RXH2 1/20 0.50
MEN1 O00255 1/20 0.50
NPC1 O15118 1/20 0.50
CA12 O43570 1/20 0.50
GMNN O75496 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7929288 0.92 KIF11 (0.58) ESR1ESR2CYP3A4TSHRLMNA
SCHEMBL7937287 0.87 ESR1 (0.76) ESR1ESR2CYP3A4TSHRLMNA
SCHEMBL7937977 0.85 ESR1 (0.64) ESR1ESR2CYP3A4TSHRLMNA
SCHEMBL7940616 0.85 ESR1 (0.64) ESR1ESR2CYP3A4TSHRLMNA
SCHEMBL7938430 0.85 NR1H2 (0.64) ESR1ESR2CYP3A4TSHRLMNA
SCHEMBL8067180 0.83 ESR1 (0.78) ESR1ESR2CYP3A4TSHRLMNA
SCHEMBL7938509 0.83 ESR1 (0.39) ESR1ESR2CYP3A4TSHRLMNA
SCHEMBL7929201 0.83 LMNA (0.65) ESR1ESR2CYP3A4LMNATYR
SCHEMBL9816151 0.83 TSHR (0.67) CYP3A4TSHRLMNAMEN1KMT2A
SCHEMBL545084 0.83 TSHR (0.67) CYP3A4TSHRLMNAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 470 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114583088-A Quantum dot light-emitting diode and preparation method thereof TCL科技集团股份有限公司 2022-06-03 CN claimed
WO-2022111583-A1 QUANTUM DOT LIGHT-EMITTING DIODE AND PREPARATION METHOD THEREFOR TCL科技集团股份有限公司 2022-06-02 WO claimed
US-5071812-A Catalyst comprising the reaction product of a tungsten or molybdenum salt and a borohydride SHELL OIL COMPANY (US) 1991-12-10 US claimed
US-5028672-A Catalyst and process for polymerization of norbornene derivatives SHELL OIL COMPANY (US) 1991-07-02 US claimed
US-4994426-A Catalyst and process for polymerization of norbornene derivatives SHELL OIL COMPANY (US) 1991-02-19 US claimed
EP-0336486-A2 Polymerization of norbornene derivatives and catalytic system suitable for use therein SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1989-10-11 EP claimed
JP-57051808-A None JP disclosed
CN-118326070-A Rapid detection method for rape black shank based on RPA-Cas12a 华中农业大学 2024-07-12 CN disclosed
CN-118291443-A Geotrichum candidum DNA extraction process 德州市荣光生物科技有限公司 2024-07-05 CN disclosed
US-12018275-B2 Delivery and use of the CRISPR-CAS systems, vectors and compositions for hepatic targeting and therapy THE BROAD INSTITUTE, INC. (US) 2024-06-25 US disclosed
US-20240200118-A1 COMPOSITIONS AND METHODS FOR OPTIMIZING TROPISM OF DELIVERY SYSTEMS FOR RNA RENAGADE THERAPEUTICS MANAGEMENT INC. 2024-06-20 US disclosed
US-11999948-B2 Methods of producing size-selected nucleic acid libraries and compositions and kits for practicing same THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-06-04 US disclosed
EP-4337774-A1 PROGRAMMABLE NANOENCAPSULATION FOR DELIVERY OF PROBIOTICS IN VIVO The Trustees of Columbia University in the City of New York (US) 2024-03-20 EP disclosed
US-4252662-A EROSION INHIBITOR STAUFFER CHEMICAL COMPANY (US) 1981-02-24 US disclosed
EP-0016450-A1 Synthetic fur and process for preparation thereof TEIJIN LIMITED (JP) 1980-10-01 EP disclosed
EP-0004447-A2 Preparation of trifluoromethylphenols and novel trifluoromethylphenyl benzyl ether intermediates ELI LILLY AND COMPANY (US) 1979-10-03 EP disclosed
US-4168388-A Trifluoromethylphenyl benzyl ethers ELI LILLY AND COMPANY (US) 1979-09-18 US disclosed
US-4046656-A Photochlorination process for methyl aromatic compounds THE DOW CHEMICAL COMPANY (US) 1977-09-06 US disclosed
US-3956154-A AIRCRAFT STAUFFER CHEMICAL COMPANY (US) 1976-05-11 US disclosed
JP-S05751808-A 0001-01-01 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240200118-A1 COMPOSITIONS AND METHODS FOR OPTIMIZING TROPISM OF DELIVERY SYSTEMS FOR RNA NSUN3, PHAX, RNGTT ESR1 1931/4885ESR2 2193/4885CYP3A4 4844/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.