Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 5/20 | 0.34 |
| ▸ | RAB9A | P51151 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | FGF23 | Q9GZV9 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2155033 | 0.80 | KIF11 (0.44) | KIF11 | |
| SCHEMBL2153842 | 0.77 | RIPK1 (0.32) | — | |
| SCHEMBL10682585 | 0.75 | CYP1A2 (0.34) | TSHRLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2154033 | 0.74 | CA1 (0.41) | TSHRNISCHLMNANPC1RAB9A | |
| SCHEMBL6041001 | 0.74 | ALDH1A1 (0.35) | LMNAALDH1A1 | |
| SCHEMBL27987679 | 0.72 | KIF11 (0.43) | KIF11TSHRHTR1DADRA1ANISCH | |
| SCHEMBL4774276 | 0.71 | MAPT (0.40) | KIF11NISCHLMNAKDM4ETP53 | |
| SCHEMBL3423876 | 0.67 | KIF11 (0.70) | KIF11TSHRHTR1DADRA1ANISCH | |
| SCHEMBL26915 | 0.67 | KIF11 (0.70) | KIF11TSHRHTR1DADRA1ANISCH | |
| Formaldehyde SCHEMBL27609400 | 0.67 | KIF11 (0.38) | KIF11TSHRHTR1DADRA1ANISCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836208-A2 | AMINO-IMIDAZOLONES FOR THE INHIBITION OF ß-SECRETASE | Wyeth Incoporated (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006076284-A2 | AMINO-IMIDAZOLONES FOR THE INHIBITION OF ß-SECRETASE | WYETH (US) | 2006-07-20 | — | — | WO | disclosed |