Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 4/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.43 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.43 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4613460 | 0.87 | NPSR1 (0.60) | PREPNPSR1KMT2AALDH1A1TP53 | |
| SCHEMBL7982004 | 0.86 | PREP (0.49) | PREPNPSR1KMT2AACEALDH1A1 | |
| SCHEMBL380893 | 0.85 | PREP (0.57) | PREPNPSR1KMT2AALDH1A1TP53 | |
| SCHEMBL10844332 | 0.84 | PREP (0.55) | PREPKMT2AACEHSD17B10DRD4 | |
| SCHEMBL8202867 | 0.82 | PREP (0.47) | PREPNPSR1ALDH1A1LMNAGFER | |
| SCHEMBL12272394 | 0.81 | PREP (0.66) | PREPNPSR1KMT2AACEALDH1A1 | |
| SCHEMBL11764594 | 0.80 | PREP (0.71) | PREPKMT2AACEALDH1A1 | |
| SCHEMBL2228388 | 0.80 | PREP (0.71) | PREPKMT2AACEALDH1A1 | |
| SCHEMBL10589596 | 0.80 | PREP (0.52) | PREPKMT2ABCHEHDAC1DRD4 | |
| SCHEMBL5575952 | 0.80 | PREP (0.52) | PREPKMT2ABCHEHDAC1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0967285-B1 | expression vector for prolylendopeptidase from Flavobacterium meningosepticum | NOVARTIS AG (CH) | 2007-09-12 | — | — | EP | disclosed |
| EP-0524906-B1 | DNA coding for prolylendopeptidase and use thereof | NOVARTIS AG (CH) | 2003-04-16 | — | — | EP | disclosed |
| US-6284511-B1 | GENERATING MUTANT DNA SEQUENCE LIBRARY; SCREENING | JAPAT LIMITED (CH) | 2001-09-04 | — | — | US | disclosed |
| US-6156554-A | Heat-stable prolylendopeptidase | CIBA GEIGY JAPAN LIMITED (JP) | 2000-12-05 | — | — | US | disclosed |
| EP-0967285-A1 | Prolylendopeptidase from Flavobacterium meningosepticum | Ciba-Geigy Japan Limited (JP) | 1999-12-29 | — | — | EP | disclosed |
| EP-0672648-B1 | Threo (2R,3S)-3-amino-2-hydroxypentanoic acid and threo (2R,3S)-3-(p-methoxy-benzyloxycarbonyl/FMOC) amino-2-hydroxy-pentanoic acid | ZAIDAN HOJIN BISEIBUTSU (JP) | 1998-09-23 | — | — | EP | disclosed |
| EP-0772685-A1 | HEAT-STABLE PROLYLENDOPEPTIDASE | Ciba-Geigy Japan Limited (JP) | 1997-05-14 | — | — | EP | disclosed |
| US-5521081-A | DNA molecule encoding prokaryotic prolylendopeptidase | CIBA-GEIGY (JAPAN) LIMITED (JP) | 1996-05-28 | — | — | US | disclosed |
| WO-1996000293-A1 | HEAT-STABLE PROLYLENDOPEPTIDASE | JAPAT LTD. (CH) | 1996-01-04 | — | — | WO | disclosed |
| EP-0672648-A1 | Threo-3-amino-2-hydroxypentanoic acid and threo (2R,3S), (2S,3R)-3-(p-methoxy-benzyloxycarbonyl) amino-2-hydroxy-pentanoic acid | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1995-09-20 | — | — | EP | disclosed |
| EP-0423358-A1 | POSTOSTATIN AND RELATED COMPOUND THEREOF, OR THEIR SALTS | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1991-04-24 | — | — | EP | disclosed |
| US-4873342-A | ANTI-AMNESIC AGENT | SUNTORY LIMITED (JP) | 1989-10-10 | — | — | US | disclosed |
| US-4810721-A | ANTIAMNESIA | SUNTORY LIMITED (JP) | 1989-03-07 | — | — | US | disclosed |
| US-4772587-A | ANTIAMMESIA AGENT, PROLYL ENDOPEPTIDASE INHIBITOR | SUNTORY LIMITED (JP) | 1988-09-20 | — | — | US | disclosed |
| EP-0268281-A2 | Pyrrolidineamide derivative having anti-prolyl endopeptidase activity, compositions comprising the same, processes for the preparation of the same, and the use of the same for the preparation of a medicament of therapeutic value | SUNTORY LIMITED (JP) | 1988-05-25 | — | — | EP | disclosed |
| US-4743616-A | ANTIAMNESIA AGENTS | SUNTORY LIMITED (JP) | 1988-05-10 | — | — | US | disclosed |
| US-4701465-A | ANTI-AMNESIC AGENTS | SUNTORY LIMITED (JP) | 1987-10-20 | — | — | US | disclosed |
| EP-0201742-A2 | N-Acylpyrrolidine derivatives, processes for preparing them, pharmaceutical composition and use | SUNTORY LIMITED (JP) | 1986-11-20 | — | — | EP | disclosed |
| EP-0201741-A2 | Dipeptide derivatives, processes for preparing them, pharmaceutical composition and use | SUNTORY LIMITED (JP) | 1986-11-20 | — | — | EP | disclosed |
| EP-0201743-A2 | Dipeptide derivatives of fatty acids, process for preparing them, pharmaceutical composition and use | SUNTORY LIMITED (JP) | 1986-11-20 | — | — | EP | disclosed |