Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | REN | P00797 | 1/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.42 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | FAP | Q12884 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264694 | 0.86 | PREP (0.55) | PREPALDH1A1NPSR1CTRB1TP53 | |
| SCHEMBL10956381 | 0.83 | PREP (0.55) | PREPALDH1A1CYP3A4RENCMA1 | |
| SCHEMBL4613460 | 0.81 | NPSR1 (0.60) | PREPALDH1A1CYP3A4NPSR1CTRB1 | |
| SCHEMBL10656619 | 0.80 | PREP (0.55) | PREPALDH1A1CYP3A4RENACE | |
| SCHEMBL8417704 | 0.78 | TGM2 (0.51) | HTRA1 | |
| SCHEMBL11517511 | 0.76 | PREP (0.70) | PREPALDH1A1CYP3A4RENCMA1 | |
| SCHEMBL7041303 | 0.76 | PREP (0.45) | PREPALDH1A1HTRA1 | |
| SCHEMBL11515816 | 0.75 | PREP (0.66) | PREPALDH1A1CYP3A4RENCMA1 | |
| SCHEMBL11517201 | 0.75 | PREP (0.68) | PREPALDH1A1CYP3A4RENCMA1 | |
| SCHEMBL22811264 | 0.75 | ACE (0.57) | PREPFAPLMNAACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6284511-B1 | GENERATING MUTANT DNA SEQUENCE LIBRARY; SCREENING | JAPAT LIMITED (CH) | 2001-09-04 | — | — | US | disclosed |
| US-6156554-A | Heat-stable prolylendopeptidase | CIBA GEIGY JAPAN LIMITED (JP) | 2000-12-05 | — | — | US | disclosed |
| EP-0772685-A1 | HEAT-STABLE PROLYLENDOPEPTIDASE | Ciba-Geigy Japan Limited (JP) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996000293-A1 | HEAT-STABLE PROLYLENDOPEPTIDASE | JAPAT LTD. (CH) | 1996-01-04 | — | — | WO | disclosed |