Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5261078 | 0.87 | CYP3A4 (0.34) | KDM4ECYP3A4CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL4169299 | 0.79 | SMN1; SMN2 (0.44) | CA2KDM4EHSD17B10CYP3A4CYP2C9 | |
| SCHEMBL6634450 | 0.76 | ALDH1A1 (0.35) | KDM4EHSD17B10CYP3A4CYP2C9SMN1; SMN2 | |
| SCHEMBL6635042 | 0.75 | CYP3A4 (0.59) | CYP3A4CYP2C9CYP2D6CYP2C19CYP1A2 | |
| SCHEMBL4163641 | 0.71 | CYP3A4 (0.49) | KDM4EHSD17B10CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL6353312 | 0.68 | SMN1; SMN2 (0.53) | KDM4EHSD17B10CYP3A4CYP1A2SMN1; SMN2 | |
| SCHEMBL7014171 | 0.68 | ADORA3 (0.42) | KDM4EHSD17B10CYP2D6CYP2C19CYP1A2 | |
| SCHEMBL4170737 | 0.68 | CA12 (0.39) | CA2KDM4ECYP3A4CYP2C9CYP2D6 | |
| SCHEMBL4573822 | 0.67 | CA12 (0.48) | CA2KDM4EHSD17B10CYP3A4CYP2C9 | |
| SCHEMBL6214346 | 0.67 | SMN1; SMN2 (0.51) | KDM4EHSD17B10CYP3A4CYP2C9CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1491542-B1 | Intermediate compounds for the preparation of imidazo-pyridine-derivatives | ASTRAZENECA AB (SE) | 2007-09-05 | — | — | EP | claimed |
| EP-1105391-B1 | Imidazo[1,2-a]pyridine compounds that inhibit gastric acid secretion, pharmaceutical compositions thereof, and processes for thier preparation | ASTRAZENECA AB (SE) | 2004-10-27 | — | — | EP | claimed |