Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 2/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.57 |
| ▸ | HTR1A | P08908 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264311 | 0.90 | ADRA1D (0.53) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL5264783 | 0.84 | DRD2 (0.51) | HTR1ADRD2HTR7DRD3 | |
| SCHEMBL5263941 | 0.84 | MEN1 (0.57) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL5270524 | 0.82 | MEN1 (0.54) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL5266680 | 0.81 | SLC6A2 (0.47) | HTR1ADRD2HTR7DRD3 | |
| SCHEMBL5270523 | 0.81 | ADRA1B (0.54) | ADRA1DADRA1AADRA1BHTR1AMEN1 | |
| SCHEMBL5265183 | 0.79 | DRD4 (0.48) | ADRA1DADRA1AADRA1BHTR1AKDM4E | |
| SCHEMBL5262999 | 0.78 | DRD2 (0.54) | HTR1ADRD2HTR7DRD3 | |
| SCHEMBL5265027 | 0.78 | DRD4 (0.47) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL5264352 | 0.78 | SMN1; SMN2 (0.55) | ADRA1AHTR1ADRD2HTR2CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833800-A1 | PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | AstraZeneca AB (SE) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006071730-A1 | PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | ASTRAZENECA AB (SE) | 2006-07-06 | — | — | WO | disclosed |